Katulanda G W, Katulanda P, Dematapitiya C, Dissanayake H A, Wijeratne S, Sheriff M H R, Matthews D R
Medical Research Institute, Colombo, 08, Sri Lanka.
Diabetes Research Unit, Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
BMC Endocr Disord. 2019 Jan 22;19(1):11. doi: 10.1186/s12902-019-0343-x.
Fasting plasma glucose (FPG) is the most commonly used screening tool for diabetes in Sri Lanka. Cut-off values from American Diabetes Association recommendations are adopted in the absence of local data. We aimed to establish FPG cut offs for Sri Lankans to screen for diabetes and pre-diabetes.
Data on FPG and diabetes/pre-diabetes status were obtained from Sri Lanka Diabetes and Cardiovascular Study (SLDCS), a community based island wide observational study conducted in 2005-6. Sensitivity specificity and area under the ROC curve were calculated for different FPG values.
Study included 4014 community dwelling people after excluding people already on treatment for diabetes or pre-diabetes. Mean age was 45.3 (± 15) years and 60.4% were females. FPG cut off of 5.3 mmol/L showed better sensitivity and specificity than 5.6 mmol/L in detecting diabetes (87.8% and 84.4% Vs 80.8% and 92.1%) and pre-diabetes (54.7% and 87.0% Vs 43.8% and 94.2%).
A lower FPG cut off of 5.3 mmol/L has a better sensitivity and acceptable specificity in screening for diabetes and pre-diabetes in Sri Lankan adults.
空腹血糖（FPG）是斯里兰卡最常用的糖尿病筛查工具。在缺乏本地数据的情况下，采用了美国糖尿病协会推荐的临界值。我们旨在确定斯里兰卡人筛查糖尿病和糖尿病前期的FPG临界值。
FPG和糖尿病/糖尿病前期状态的数据来自2005 - 2006年在全岛社区开展的观察性研究——斯里兰卡糖尿病与心血管疾病研究（SLDCS）。计算不同FPG值的敏感性、特异性和ROC曲线下面积。
排除已接受糖尿病或糖尿病前期治疗的人群后，研究纳入了4014名社区居民。平均年龄为45.3（±15）岁，女性占60.4%。在检测糖尿病（87.8%和84.4%对比80.8%和92.1%）和糖尿病前期（54.7%和87.0%对比43.8%和94.2%）方面，5.3 mmol/L的FPG临界值比5.6 mmol/L显示出更好的敏感性和特异性。
较低的FPG临界值5.3 mmol/L在筛查斯里兰卡成年人糖尿病和糖尿病前期时具有更好的敏感性和可接受的特异性。
