Wheeler A W, Henderson D C, Youlten L J, Al-Janabi I I, Hickman B E, Taylor I H, Moran D M
Int Arch Allergy Appl Immunol. 1987;83(4):354-8. doi: 10.1159/000234368.
An acid-insoluble, methacrylic acid, methyl methacrylate copolymer (Eudragit L-100) was used to give an enteric coating to a grass pollen extract in order to protect it against gastric degradation. Substantial protection against the degradative effects of simulated gastric secretion was demonstrated using this preparation which was well tolerated by grass pollen-allergic volunteers. The enteric-coated allergen induced a greater secondary antibody response than did an aqueous presentation when administered orally to guinea pigs which had been primed previously by subcutaneous injection. This result indicates that an effective hyposensitisation regimen could consist of a short series of initial parenteral injections, followed by an oral course of the protected allergen.
一种酸不溶性的甲基丙烯酸与甲基丙烯酸甲酯共聚物（尤特奇L-100）被用于给草花粉提取物包肠溶衣，以保护其免受胃部降解。使用该制剂可有效抵御模拟胃液分泌的降解作用，且草花粉过敏志愿者对其耐受性良好。当对先前经皮下注射致敏的豚鼠口服给药时，肠溶衣过敏原诱导产生的二次抗体反应比水剂更强。这一结果表明，一种有效的减敏方案可以包括一系列短程的初始皮下注射，随后口服受保护的过敏原。
