Oral hyposensitisation with enteric-coated allergens as extension therapy following a basic subcutaneous course of injections.

We investigated in grass-pollen-sensitive adults the efficacy and safety of a therapeutic hyposensitisation regimen consisting of a basic pre-seasonal course of tyrosine-absorbed glutaraldehyde-modified grass pollen extract (Pollinex), followed by oral extension treatment using encapsulated, particulate, enteric-coated grass pollen allergen. The daily recorded symptom scores both of these patients and of others treated with complete basic and extension courses of Pollinex indicated that both sets of patients had fared better during the grass pollen season than control patients who had received only the basic Pollinex injections.