Rebien W, Puttonen E, Maasch H J, Stix E, Wahn U
Eur J Pediatr. 1982 Jul;138(4):341-4. doi: 10.1007/BF00442513.
Forty children allergic to grass pollen were divided into two groups, and matched by their serum IgE antibody concentrations to grasses. For two preseasonal treatment periods one group received immunotherapy with an alum adsorbed grass pollen extract, while the second group was treated orally with an aqueous extract of the same allergens. The patients' postseasonal self evaluation as well as the mean symptom scores calculated from symptom diaries indicate, that oral treatment is significantly less effective in controlling seasonal allergic symptoms than subcutaneous immunotherapy. During oral treatment neither an increase of specific serum IgG antibodies, nor a suppression of the seasonal increase in specific serum IgE antibodies could be demonstrated.
40名对草花粉过敏的儿童被分成两组，并根据他们血清中针对草的IgE抗体浓度进行匹配。在两个季前治疗期内，一组接受明矾吸附草花粉提取物的免疫疗法，而另一组口服相同过敏原的水提取物进行治疗。患者的季后自我评估以及根据症状日记计算出的平均症状评分表明，口服治疗在控制季节性过敏症状方面明显不如皮下免疫疗法有效。在口服治疗期间，既未发现特异性血清IgG抗体增加，也未发现特异性血清IgE抗体季节性增加受到抑制。
