代谢组学在妊娠肝内胆汁淤积症中的应用：系统评价。
Application of metabolomics in intrahepatic cholestasis of pregnancy: a systematic review.
机构信息
Department of Epidemiology and Health Statistics, Medical College of Soochow University, Suzhou, China.
Department of Obstetrics, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Nanjing Medical University, Suzhou, Jiangsu, China.
出版信息
Eur J Med Res. 2022 Sep 14;27(1):178. doi: 10.1186/s40001-022-00802-z.
BACKGROUND
Intrahepatic cholestasis of pregnancy (ICP) is a severe idiopathic disorder of bile metabolism; however, the etiology and pathogenesis of ICP remain unclear.
AIMS
This study comprehensively reviewed metabolomics studies related to ICP, to help in identifying the pathophysiological changes of ICP and evaluating the potential application of metabolomics in its diagnosis.
METHODS
Relevant articles were searched through 2 online databases (PubMed and Web of Science) from January 2000 to March 2022. The metabolites involved were systematically examined and compared. Pathway analysis was conducted through the online software MetaboAnalyst 5.0.
RESULTS
A total of 14 papers reporting 212 metabolites were included in this study. There were several highly reported metabolites: bile acids, such as glycocholic acid, taurochenodeoxycholic acid, taurocholic acid, tauroursodeoxycholic acid, and glycochenodeoxycholic acid. Dysregulation of metabolic pathways involved bile acid metabolism and lipid metabolism. Metabolites related to lipid metabolism include phosphatidylcholine, phosphorylcholine, phosphatidylserine, sphingomyelin, and ceramide.
CONCLUSIONS
This study provides a systematic review of metabolomics of ICP and deepens our understanding of the etiology of ICP.
背景
妊娠肝内胆汁淤积症（ICP）是一种严重的胆汁代谢特发性疾病，但 ICP 的病因和发病机制仍不清楚。
目的
本研究综合综述了与 ICP 相关的代谢组学研究，以帮助识别 ICP 的病理生理变化，并评估代谢组学在其诊断中的潜在应用。
方法
通过 2 个在线数据库（PubMed 和 Web of Science）从 2000 年 1 月至 2022 年 3 月检索相关文献。系统检查和比较所涉及的代谢物。通过在线软件 MetaboAnalyst 5.0 进行途径分析。
结果
本研究共纳入 14 篇报道 212 种代谢物的文献。有几种高度报道的代谢物：胆汁酸，如甘氨胆酸、牛磺鹅脱氧胆酸、胆酸、牛磺熊脱氧胆酸和甘氨鹅脱氧胆酸。代谢途径的失调涉及胆汁酸代谢和脂质代谢。与脂质代谢相关的代谢物包括磷脂酰胆碱、磷酸胆碱、磷脂酰丝氨酸、鞘磷脂和神经酰胺。
结论
本研究对 ICP 的代谢组学进行了系统综述，加深了我们对 ICP 病因的理解。
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