Smith E L, Harwerth R S, Crawford M L, von Noorden G K
Invest Ophthalmol Vis Sci. 1987 Aug;28(8):1236-45.
The consistency of the refractive error alterations produced by monocular form deprivation in developing monkeys and the influence of the duration and the age at the onset of deprivation on the magnitude of these alterations was investigated. Refractive error and axial length measurements are presented for a group of monkeys which had one eye sutured closed for a period exceeding 18 months beginning at various ages ranging from 26 days to 25 months. In addition, we pooled and reanalyzed refractive error and axial length data for monocularly form-deprived monkeys from previous studies. When the alterations in the deprived eye's refractive status are specified with respect to the fellow nondeprived eye, the results are, with a few noteworthy exceptions, consistent between laboratories and individual animals. In most cases, early monocular form deprivation causes the treated eye to develop a longer axial length and to manifest a more myopic/less hyperopic refractive error than the fellow nontreated eye. The magnitude of this deprivation-induced alteration is generally dependent on the duration and the age at the onset of form deprivation. The earlier the deprivation is initiated and the longer it is maintained, the greater the degree of the relative myopia produced in the deprived eye.
研究了发育中的猴子单眼形觉剥夺所产生的屈光不正改变的一致性，以及剥夺持续时间和剥夺开始时的年龄对这些改变程度的影响。给出了一组猴子的屈光不正和眼轴长度测量数据，这些猴子从26天到25个月的不同年龄开始，将一只眼睛缝合闭合超过18个月。此外，我们汇总并重新分析了先前研究中接受单眼形觉剥夺的猴子的屈光不正和眼轴长度数据。当相对于对侧未剥夺眼来确定剥夺眼屈光状态的改变时，除了一些值得注意的例外情况，各实验室之间以及个体动物之间的结果是一致的。在大多数情况下，早期单眼形觉剥夺会使被处理的眼睛比未处理的对侧眼睛眼轴更长，屈光不正更近视/远视程度更低。这种剥夺诱导的改变程度通常取决于形觉剥夺的持续时间和开始时的年龄。剥夺开始得越早且持续时间越长，剥夺眼产生的相对近视程度就越大。
