Chakraborty R
Heredity (Edinb). 1987 Aug;59 ( Pt 1):19-28. doi: 10.1038/hdy.1987.92.
Using the theory of additive genetic variability of a polygenic trait, it is shown that an individual's heterozygosity at the loci governing the trait cannot be determined accurately from observations on phenotypes alone. Furthermore, the negative association between heterozygosity and phenotypic variance, and a positive correlation of the frequency of the modal class of a phenotypic trait and the extent of heterozygosity can be explained by additive allelic effects. It is argued that while the number of heterozygous loci in an individual may not be a good indicator of the individual's genomic heterozygosity, there is evidence that some of the biochemical loci may reflect genetic variation at the loci controlling phenotypic polymorphism. Thus the observed relationship between biochemical heterozygosity and phenotypic variance may not constitute hard evidence of heterosis, overdominance, or associative overdominance.
运用多基因性状的加性遗传变异理论可知，仅根据表型观察无法准确确定个体在控制该性状的基因座上的杂合性。此外，杂合性与表型方差之间的负相关，以及表型性状模态类频率与杂合性程度之间的正相关，可以通过加性等位基因效应来解释。有人认为，虽然个体中杂合基因座的数量可能不是个体基因组杂合性的良好指标，但有证据表明，一些生化基因座可能反映了控制表型多态性的基因座上的遗传变异。因此，观察到的生化杂合性与表型方差之间的关系可能并不构成杂种优势、超显性或关联超显性的确凿证据。
