CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China.
University of Chinese Academy of Sciences, Beijing, People's Republic of China.
Emerg Microbes Infect. 2022 Dec;11(1):2412-2422. doi: 10.1080/22221751.2022.2125348.
The devastating economic and public health consequences caused by the COVID-19 pandemic have prompted outstanding efforts from the scientific community and pharmaceutical companies to develop antibody-based therapeutics against SARS-CoV-2. Those efforts are encouraging and fruitful. An unprecedentedly large number of monoclonal antibodies (mAbs) targeting a large spectrum of epitopes on the spike protein has been developed in the last two years. The development of structural biology, especially the cryo-EM technology, provides structural insights into the molecular neutralizing mechanisms of those mAbs. Moreover, neutralizing antibodies are essential in protecting host from infection. Therefore, understanding the antibody neutralizing mechanism is critical for optimizing effective antibody-based therapeutics and developing next-generation pan-coronavirus vaccines. This review summarizes the latest understanding of antibody neutralizing mechanisms against SARS-CoV-2 at the molecular and structural levels.
由 COVID-19 大流行造成的灾难性经济和公共卫生后果促使科学界和制药公司做出了杰出努力，开发针对 SARS-CoV-2 的基于抗体的疗法。这些努力令人鼓舞，也富有成效。在过去两年中，已经开发出了大量针对刺突蛋白上广泛表位的单克隆抗体（mAbs）。结构生物学的发展，特别是冷冻电镜技术，为这些 mAbs 的分子中和机制提供了结构见解。此外，中和抗体对于保护宿主免受感染至关重要。因此，了解抗体中和机制对于优化有效的基于抗体的治疗方法和开发下一代泛冠状病毒疫苗至关重要。本综述总结了在分子和结构水平上针对 SARS-CoV-2 的抗体中和机制的最新理解。
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