School of Optometry & Vision Science, University of Waterloo, Waterloo, ON, Canada.
Chicago College of Optometry, Midwestern University, Downers Grove, IL, USA.
J Vis. 2022 Sep 2;22(10):14. doi: 10.1167/jov.22.10.14.
Short-term deprivation of one eye by monocular patching causes a temporary increase in the contribution of that eye to binocular vision when the eye patch is removed. This effect, known as ocular dominance plasticity, provides a model of neuroplasticity within the human binocular visual system. We investigated whether physical exercise and the non-invasive brain stimulation technique transcranial random noise stimulation (tRNS), two interventions that may increase visual cortex neuroplasticity, enhance ocular dominance plasticity when delivered individually or in combination. Ocular dominance was measured using a grating rivalry test and a dichoptic letter contrast polarity judgment test. We observed robust ocular dominance changes for both outcome measures following 2-hour monocular deprivation; however, the magnitude of the effect was not influenced by exercise or tRNS. Ocular dominance plasticity may already be maximal after 2 hours of monocular deprivation in those with normal vision and therefore cannot be augmented by interventions designed to enhance neuroplasticity.
短期剥夺一只眼睛的单眼遮蔽会导致当眼罩取下时，该眼睛对双眼视觉的贡献暂时增加。这种效应，称为眼优势可塑性，为人类双眼视觉系统内的神经可塑性提供了一个模型。我们研究了两种干预措施，即体育锻炼和非侵入性脑刺激技术经颅随机噪声刺激（tRNS），是否可以增强视觉皮层的神经可塑性，从而增强单独或联合使用时的眼优势可塑性。使用光栅竞争测试和双眼字母对比度极性判断测试来测量眼优势。我们观察到，在 2 小时的单眼剥夺后，两种结果测量都有明显的眼优势变化；然而，运动或 tRNS 并没有影响到效果的大小。在正常视力的情况下，单眼剥夺 2 小时后，眼优势可塑性可能已经达到最大值，因此，旨在增强神经可塑性的干预措施无法增强其效果。
