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一名有桥本甲状腺炎病史的孕妇被诊断为菊池-藤本病:首例病例报告。

A pregnant women with history of hashimoto's thyroiditis diagnosed with Kikuchi-Fujimoto disease: the first case report.

作者信息

Bazkke Bashar, Osman Joli, Shahrour Mohammad, Ziadeh Mohammad, Haji Mohamad Aya, Mouhandes Mohamed Imad Eddin, Niazi Ammar

机构信息

Faculty of Medicine, University of Aleppo, Aleppo, Syria.

Department of Pathology, Faculty of Medicine, University of Aleppo, Aleppo, Syria.

出版信息

Thyroid Res. 2022 Sep 15;15(1):16. doi: 10.1186/s13044-022-00135-3.

Abstract

BACKGROUND

Kikuchi-Fujimoto disease (KFD) is a benign, self-limiting disorder characterized by regional lymphadenopathy. Clinical symptoms range from mild fever and tenderness to upper respiratory syndrome. A few cases have been observed during pregnancy or Hashimoto's disease. What we describe here is the first observed case of KFD in a pregnant woman with a history of Hashimoto's thyroiditis.

CASE PRESENTATION

A 36-year-old woman presented to Aleppo University Hospital during the 13 week of gestation with a painful cervical node on the right side of her neck. The patient's previous medical history confirmed Hashimoto's thyroiditis for several years. After histopathological examinations and radiological investigations, she was diagnosed with Kikuchi-Fujimoto disease and treated with corticosteroids. Although the patient did not adhere to the treatment very well due to her concerns for the fetus, the clinical picture improved after delivery. The patient now is on follow-up and continuing the current treatment with corticosteroids.

CONCLUSIONS

Further investigations need to be conducted to understand the possible autoimmune etiology of KFD when it is associated with Hashimoto's thyroiditis disease. It is also necessary to understand the relationship between this disease and pregnancy.

摘要

背景

菊池-藤本病(KFD)是一种以局部淋巴结病为特征的良性自限性疾病。临床症状从轻度发热和压痛到上呼吸道综合征不等。在妊娠期间或桥本氏病期间观察到少数病例。我们在此描述的是首例有桥本氏甲状腺炎病史的孕妇发生菊池-藤本病的病例。

病例介绍

一名36岁女性在妊娠13周时因右侧颈部疼痛性淋巴结就诊于阿勒颇大学医院。患者既往病史证实患有桥本氏甲状腺炎数年。经过组织病理学检查和影像学检查,她被诊断为菊池-藤本病并接受了皮质类固醇治疗。尽管由于患者担心胎儿而未很好地坚持治疗,但产后临床症状有所改善。患者目前正在接受随访并继续使用皮质类固醇进行当前治疗。

结论

当菊池-藤本病与桥本氏甲状腺炎相关时,需要进一步研究以了解其可能的自身免疫病因。了解这种疾病与妊娠之间的关系也很有必要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c79d/9476254/3283a7c94d81/13044_2022_135_Fig1_HTML.jpg

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