Gu Lihua, Shu Hao, Wang Yanjuan, Xu Hui
Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China.
Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.
Front Aging Neurosci. 2022 Aug 30;14:966525. doi: 10.3389/fnagi.2022.966525. eCollection 2022.
Previous neuroimaging studies reported inconsistent results for comparison between Parkinson's disease (PD) with impulse control disorder (PD-ICD) and without ICD (PD-no ICD).
A search was performed in databases (PubMed and Web of Science) to identify studies published before May 2022. An anatomic likelihood estimation (ALE) method study was made for neuroimaging studies in PD-ICD.
The study included 20 studies (including 341 PD-ICD and 437 PD-no ICD). PD-ICD patients showed significant cortical thinning in the right inferior frontal gyrus (IFG), the right middle frontal gyrus (MFG), the left superior frontal gyrus (SFG), the right precentral gyrus (PCG) and the left cingulate gyrus (CG), compared to PD-no ICD patients. The ALE study showed reduced resting-state brain activation in the right IFG, the right PCG, the left insula and the right transverse temporal gyrus (TTG) in PD-ICD, compared to PD-no ICD patients. In addition, PD-ICD showed increased resting-state brain activation in the right caudate, the bilateral insula and the left orbital gyrus (OG), compared to PD-no ICD patients. The study indicated reduced task-related brain activation in the right caudate, the right MFG, the right lentiform nucleus (LN) and the right precuneus (PCUN) in PD-ICD, compared to PD-no ICD patients. The study showed increased task-related brain activation in the left inferior parietal lobule (IPL), the right medial frontal gyrus, the right caudate and the right PCG in PD-ICD, compared to PD-no ICD patients.
The present ALE analysis has confirmed that brain changes in frontal, temporal and basal ganglia regions are among the most frequently reported regions in PD-ICD. Deficits in these regions could play a role in diagnosis of PD-ICD.
先前的神经影像学研究报告显示，帕金森病（PD）伴冲动控制障碍（PD-ICD）与不伴冲动控制障碍（PD-no ICD）患者之间的比较结果并不一致。
在数据库（PubMed和Web of Science）中进行检索，以识别2022年5月之前发表的研究。对PD-ICD的神经影像学研究采用了解剖似然估计（ALE）方法。
该研究纳入了20项研究（包括341例PD-ICD患者和437例PD-no ICD患者）。与PD-no ICD患者相比，PD-ICD患者在右侧额下回（IFG）、右侧额中回（MFG）、左侧额上回（SFG）、右侧中央前回（PCG）和左侧扣带回（CG）出现明显的皮质变薄。ALE研究显示，与PD-no ICD患者相比，PD-ICD患者右侧IFG、右侧PCG、左侧岛叶和右侧颞横回（TTG）的静息态脑激活减少。此外，与PD-no ICD患者相比，PD-ICD患者右侧尾状核、双侧岛叶和左侧眶回（OG）的静息态脑激活增加。该研究表明，与PD-no ICD患者相比，PD-ICD患者右侧尾状核、右侧MFG、右侧豆状核（LN）和右侧楔前叶（PCUN）的任务相关脑激活减少。该研究显示，与PD-no ICD患者相比，PD-ICD患者左侧顶下小叶（IPL）、右侧额内侧回、右侧尾状核和右侧PCG的任务相关脑激活增加。
目前的ALE分析证实，额叶、颞叶和基底神经节区域的脑变化是PD-ICD中最常报告的区域之一。这些区域的缺陷可能在PD-ICD的诊断中起作用。
