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病例报告:强调甲基苯丙胺和大麻同时使用对心血管的影响

Case Report Highlighting Cardiovascular Effects of Concomitant Use of Methamphetamine and Marijuana.

作者信息

Fontana Sophia, Panahi Ladan, Udeani George, Surani Salim, Desai Deepa

机构信息

Pharmacy Practice, Texas A&M University, Kingsville, USA.

Medicine, Texas A&M University, College Station, USA.

出版信息

Cureus. 2022 Aug 10;14(8):e27866. doi: 10.7759/cureus.27866. eCollection 2022 Aug.

DOI:10.7759/cureus.27866
PMID:36110480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9462887/
Abstract

We present the case of a 51-year-old male admitted for cardiovascular complications in the face of concomitant chronic methamphetamine and cannabis use. Upon further assessment, the patient exhibited cardiotoxicity, including acute to chronic congestive heart failure (CHF) exacerbation, hypercoagulable state, and electrolyte abnormalities. Cardiotoxicity secondary to chronic methamphetamine use has been established. However, marijuana's cardiovascular effects have not been well established. Even less information exists about the simultaneous use of methamphetamine and cannabis. With increasing interest in the use of marijuana for medical purposes, it is imperative to study any corresponding toxicity and adverse effect profile. The worldwide pattern of drug co-administration also brings the importance of this topic to light. This case report serves to provide insight into this information gap.

摘要

我们报告了一例51岁男性患者,该患者因同时长期使用甲基苯丙胺和大麻而出现心血管并发症入院。进一步评估发现,该患者存在心脏毒性,包括急性至慢性充血性心力衰竭(CHF)加重、高凝状态和电解质异常。长期使用甲基苯丙胺导致的心脏毒性已得到证实。然而,大麻对心血管的影响尚未完全明确。关于同时使用甲基苯丙胺和大麻的信息则更少。随着对大麻用于医疗目的的兴趣日益增加,研究其任何相应的毒性和不良反应情况势在必行。全球药物联合使用的模式也凸显了这一主题的重要性。本病例报告旨在深入探讨这一信息空白。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/232e/9462887/58aabbd1c161/cureus-0014-00000027866-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/232e/9462887/75e42651d078/cureus-0014-00000027866-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/232e/9462887/bde336367326/cureus-0014-00000027866-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/232e/9462887/58aabbd1c161/cureus-0014-00000027866-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/232e/9462887/75e42651d078/cureus-0014-00000027866-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/232e/9462887/bde336367326/cureus-0014-00000027866-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/232e/9462887/58aabbd1c161/cureus-0014-00000027866-i03.jpg

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本文引用的文献

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Metabolites of Cannabis Induce Cardiac Toxicity and Morphological Alterations in Cardiac Myocytes.大麻代谢物可导致心肌细胞中毒和形态改变。
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Methamphetamine-Associated Heart Failure Hospitalizations Across the United States: Geographic and Social Disparities.美国各地与甲基苯丙胺相关的心力衰竭住院情况:地理和社会差异
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Patterns and Characteristics of Methamphetamine Use Among Adults - United States, 2015-2018.成年人吸食甲基苯丙胺的模式和特征 - 美国,2015-2018 年。
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