甲基苯丙胺使用与心血管疾病。
Methamphetamine Use and Cardiovascular Disease.
机构信息
From the Departments of Pathology and Translational Pathobiology (C.G.K., M.S.B., G.K.K., J.G.T., A.W.O.), LSU Health Sciences Center, Shreveport, LA.
Cellular and Molecular Physiology (C.G.K., M.S.B., A.W.O.), LSU Health Sciences Center, Shreveport, LA.
出版信息
Arterioscler Thromb Vasc Biol. 2019 Sep;39(9):1739-1746. doi: 10.1161/ATVBAHA.119.312461. Epub 2019 Aug 21.
Abstract
While the opioid epidemic has garnered significant attention, the use of methamphetamines is growing worldwide independent of wealth or region. Following overdose and accidents, the leading cause of death in methamphetamine users is cardiovascular disease, because of significant effects of methamphetamine on vasoconstriction, pulmonary hypertension, atherosclerotic plaque formation, cardiac arrhythmias, and cardiomyopathy. In this review, we examine the current literature on methamphetamine-induced changes in cardiovascular health, discuss the potential mechanisms regulating these varied effects, and highlight our deficiencies in understanding how to treat methamphetamine-associated cardiovascular dysfunction.
摘要
虽然阿片类药物流行已引起广泛关注，但无论贫富或地区，全世界使用冰毒的情况都在不断增加。继过量用药和事故之后，导致冰毒使用者死亡的首要原因是心血管疾病，这是因为冰毒对血管收缩、肺动脉高压、动脉粥样硬化斑块形成、心律失常和心肌病有显著影响。在这篇综述中，我们研究了关于冰毒对心血管健康影响的现有文献，讨论了调节这些不同作用的潜在机制，并强调了我们在理解如何治疗与冰毒相关的心血管功能障碍方面的不足。
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本文引用的文献
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Crystal Methamphetamine: A Drug and Cardiovascular Epidemic.冰毒：一种毒品与心血管疾病的流行问题
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Clinical Characteristics and Outcome of Methamphetamine-Associated Pulmonary Arterial Hypertension and Dilated Cardiomyopathy.甲基苯丙胺相关性肺动脉高压和扩张型心肌病的临床特征和转归。
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