Jalaluddin Mohammad, Hashmi Aaquib, Devi Konsam Bidya, Abushanan AlWaleed, Hashem Qamar, Uthman Uthman S
Department of Periodontics and Oral Implantology, Kalinga Institute of Dental Sciences, KIIT Deemed to be University, Bhubaneswar, Odisha, India.
Department of Oral and Maxillofacial Surgery, S Nijalingappa Institute of Dental Sciences and Research, Kalaburagi, Karnataka, India.
J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S585-S588. doi: 10.4103/jpbs.jpbs_167_22. Epub 2022 Jul 13.
The aim of the current research was to evaluate the effectiveness of three desensitizing agents on the occlusion of dentinal tubules.
Eighty human maxillary and mandibular permanent premolar teeth that were subjected to extraction in the course of orthodontic treatment were utilized in this study. The teeth were subjected to sectioning by employing a double-sided diamond disk. A block was procured from every even cervical dentinal surface with dimensions of 4 mm × 4 mm × 3 mm (L × B × H) by sectioning the tooth transversely. Further, 35% phosphoric acid was utilized for 30 s to cause dentinal etching, thereby exposing the dentinal tubules. The blocks of dentin were assigned at random to one of the following four groups ( = 20): group I: control, group II: bioactive glass containing desensitizing agent, group III: 1% nano-hydroxyapatite containing desensitizing agent, group IV: tri-calcium phosphate-containing desensitizing agent. The exterior of the specimens was scanned and evaluated using a scanning electron microscope.
1% nano-hydroxyapatite-containing desensitizing agent (2.04 ± 0.08) exhibited higher mean dentinal tubular blockage, followed by the bioactive class-containing desensitizing substance (2.26 ± 0.19), tri-calcium phosphate desensitizing agent (2.84 ± 0.10), and the control group (4.18 ± 0.12) in that order. Amid the experimental groups employing the various desensitizing substances, there were significant differences statistically with < 0.001.
The current research concluded that each of the three desensitizing agents was efficient in dentinal tubular occlusion regardless of their different chemical constitution. However, it was noted that 1% nano-hydroxyapatite-containing desensitizing agent was marginally superior to the bioactive glass- and tri-calcium phosphate-containing desensitizing agents.
本研究的目的是评估三种脱敏剂对牙本质小管封闭的有效性。
本研究使用了80颗在正畸治疗过程中被拔除的人类上颌和下颌恒前磨牙。使用双面金刚石盘对牙齿进行切片。通过横向切割牙齿，从每个偶数颈面牙本质表面获取尺寸为4mm×4mm×3mm（长×宽×高）的块状物。此外，使用35%磷酸进行30秒的牙本质酸蚀，从而暴露牙本质小管。将牙本质块随机分为以下四组之一（每组 = 20）：第一组：对照组，第二组：含生物活性玻璃的脱敏剂组，第三组：含1%纳米羟基磷灰石的脱敏剂组，第四组：含磷酸三钙的脱敏剂组。使用扫描电子显微镜对标本的表面进行扫描和评估。
含1%纳米羟基磷灰石的脱敏剂（2.04±0.08）表现出更高的平均牙本质小管阻塞率，其次依次是含生物活性玻璃的脱敏剂（2.26±0.19）、磷酸三钙脱敏剂（2.84±0.10）和对照组（4.18±0.12）。在使用各种脱敏剂的实验组中，统计学上存在显著差异，P<0.001。
本研究得出结论，三种脱敏剂中的每一种在牙本质小管封闭方面都是有效的，无论其化学组成如何不同。然而，值得注意的是，含1%纳米羟基磷灰石的脱敏剂略优于含生物活性玻璃和磷酸三钙的脱敏剂。
