Fathima Kamal Hameed, Rajendran Venkateshwaran, Sekhar Prasanna, Sivasubramaniam Harish Vadivelu
Associate Professor, Department of Dentistry, Srimuthukumaran Medical College and Research Institute, Mangadu, Chennai, Tamil Nadu, India.
Reader, Department of Prosthodontics, Asan Memorial Dental College and Hospital, Keerapakkam, Chengalpattu, Tamil Nadu, India.
J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S765-S768. doi: 10.4103/jpbs.jpbs_145_22. Epub 2022 Jul 13.
The purpose of this case-control study was to evaluate the role of TNF-α in gingival crevicular fluid among obese women with chronic periodontitis.
A total of 60 subjects were randomly selected for the study. The study population was further divided into three groups (Group 1, Obese women without periodontitis; Group 2, Non-obese women without periodontitis; Group 3, Obese with chronic periodontitis). Gingival crevicular fluid samples were taken for assessment based on clinical parameters like probing depth, bleeding on probing, and BMI.
There was significant increase in the level of TNF-α in gingival crevicular fluid from obese patients with chronic periodontitis and a positive correlation was found between TNF-α levels and values of the plaque index, OHI -I and BMI.
Based on these results, it can be concluded that GCF level of TNF-α was significantly higher in obese patients with and without chronic periodontitis, and highest in obese patients with chronic periodontitis group.
本病例对照研究的目的是评估肿瘤坏死因子-α（TNF-α）在患有慢性牙周炎的肥胖女性龈沟液中的作用。
共随机选取60名受试者进行研究。研究人群进一步分为三组（第1组，无牙周炎的肥胖女性；第2组，无牙周炎的非肥胖女性；第3组，患有慢性牙周炎的肥胖者）。根据诸如探诊深度、探诊出血和体重指数等临床参数采集龈沟液样本进行评估。
患有慢性牙周炎的肥胖患者龈沟液中TNF-α水平显著升高，且TNF-α水平与菌斑指数、口腔卫生指数-I和体重指数值之间存在正相关。
基于这些结果，可以得出结论，无论有无慢性牙周炎，肥胖患者龈沟液中TNF-α水平均显著更高，且在患有慢性牙周炎肥胖患者组中最高。
