Sabu Nimmy, Thomas Nithya Annie, Thimmaiah Charisma, Joseph Ajay P, Jobe Justin, Palose Pauline Susan
Department of Pediatric and Preventive Dentistry, Indira Gandhi Institute of Dental Sciences, Kothamangalam, Kerala, India.
Department of Pediatric and Preventive Dentistry, Adhiparasakthi Dental College and Hospital, Melmaruvathur, Tamil Nadu, India.
J Pharm Bioallied Sci. 2022 Jul;14(Suppl 1):S626-S630. doi: 10.4103/jpbs.jpbs_753_21. Epub 2022 Jul 13.
Disinfection of the root canal system by biomechanical preparation and profuse irrigation is especially important in primary teeth due to its complex pulp canal anatomy. Appropriate selection of irrigating solution should be done in terms of tissue dissolving capacity, antibacterial efficacy, and palatability when treating pediatric cases.
The aim of the study was to compare the antibacterial efficacy of 2% chlorhexidine (CHX), 0.2% cetrimide (CTR), and 0.2% CHX + 0.2% CTR against anaerobic bacteria and to test the influence of CTR added to CHX on its antibacterial action.
Seventy-five teeth that were selected for the study were divided into three groups: Group I (2% CHX), Group II (0.2% CTR), and Group III (0. 2% CHX + 0.2% CTR). Samples collected before and after irrigation were immediately processed and microbial growths were quantified.
Intergroup comparison was done using one-way analysis of variance and Newman-Keuls multiple procedures and intragroup comparison was done using paired -test.
When the mean values of Group I were compared with Group II, the data were statistically not significant ( = 0.2341), whereas Group I showed a significant difference when compared with Group III ( = 0.0107). When the mean values of Group II and Group III were compared, the data were found to be statistically not significant ( = 0.0805).
The efficacy of 2% CHX was found to be slightly superior when compared with that of 0.2% CTR, but the difference was not statistically significant. However, a significant difference was found between 2% CHX and combination irrigants.
由于乳牙牙髓腔解剖结构复杂，通过生物力学预备和大量冲洗对根管系统进行消毒在乳牙治疗中尤为重要。在治疗儿童病例时，应根据组织溶解能力、抗菌效果和适口性来适当选择冲洗液。
本研究旨在比较2%氯己定（CHX）、0.2%西曲溴铵（CTR）和0.2%CHX + 0.2%CTR对厌氧菌的抗菌效果，并测试CTR添加到CHX中对其抗菌作用的影响。
选取75颗用于研究的牙齿，分为三组：第一组（2%CHX）、第二组（0.2%CTR）和第三组（0.2%CHX + 0.2%CTR）。冲洗前后收集的样本立即进行处理，并对微生物生长进行定量分析。
组间比较采用单因素方差分析和Newman-Keuls多重检验程序，组内比较采用配对检验。
将第一组的平均值与第二组比较时，数据在统计学上无显著差异（P = 0.2341），而第一组与第三组比较时显示出显著差异（P = 0.0107）。比较第二组和第三组的平均值时，发现数据在统计学上无显著差异（P = 0.0805）。
发现2%CHX的疗效略优于0.2%CTR，但差异无统计学意义。然而，2%CHX与联合冲洗液之间存在显著差异。
