CCL2-CCR2 轴在心血管疾病中的作用：发病机制和临床意义。
Role of the CCL2-CCR2 axis in cardiovascular disease: Pathogenesis and clinical implications.
机构信息
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
Hebei Key Laboratory of Integrated Traditional Chinese and Western Medicine for Diabetes and Its Complications, College of Traditional Chinese Medicine, North China University of Science and Technology, Tangshan, China.
出版信息
Front Immunol. 2022 Aug 30;13:975367. doi: 10.3389/fimmu.2022.975367. eCollection 2022.
The CCL2-CCR2 axis is one of the major chemokine signaling pathways that has received special attention because of its function in the development and progression of cardiovascular disease. Numerous investigations have been performed over the past decades to explore the function of the CCL2-CCR2 signaling axis in cardiovascular disease. Laboratory data on the CCL2-CCR2 axis for cardiovascular disease have shown satisfactory outcomes, yet its clinical translation remains challenging. In this article, we describe the mechanisms of action of the CCL2-CCR2 axis in the development and evolution of cardiovascular diseases including heart failure, atherosclerosis and coronary atherosclerotic heart disease, hypertension and myocardial disease. Laboratory and clinical data on the use of the CCL2-CCR2 pathway as a targeted therapy for cardiovascular diseases are summarized. The potential of the CCL2-CCR2 axis in the treatment of cardiovascular diseases is explored.
CCL2-CCR2 轴是主要的趋化因子信号通路之一，由于其在心血管疾病的发生和发展中的作用，受到了特别关注。在过去的几十年中，已经进行了大量的研究来探索 CCL2-CCR2 信号轴在心血管疾病中的功能。关于心血管疾病的 CCL2-CCR2 轴的实验室数据显示出了令人满意的结果，但它的临床转化仍然具有挑战性。在本文中，我们描述了 CCL2-CCR2 轴在包括心力衰竭、动脉粥样硬化和冠状动脉粥样硬化性心脏病、高血压和心肌病在内的心血管疾病的发展和演变中的作用机制。总结了 CCL2-CCR2 途径作为心血管疾病靶向治疗的实验室和临床数据。探讨了 CCL2-CCR2 轴在心血管疾病治疗中的潜力。
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