Department of Biotechnology and Biosciences, University of Milano - Bicocca, Piazza della Scienza 2, 20126, Milano, Italy.
Department of Electronics, Information and Bioengineering, Politecnico di Milano (Italy), Piazza Leonardo da Vinci 32, 20133, Milano, Italy.
Chem Asian J. 2022 Nov 16;17(22):e202200797. doi: 10.1002/asia.202200797. Epub 2022 Oct 5.
This review aims at giving selected chemical and mechanical insights on design criteria that should be taken into account in hydrogel production for biomedical applications. Particular emphasis will be given to the chemical aspects involved in hydrogel design: macromer chemical composition, cross-linking strategies and chemistry towards "conventional" and smart/stimuli responsive hydrogels. Mechanical properties of hydrogels in view of regenerative medicine applications will also be considered.
本文旨在就生物医学应用水凝胶制备中需考虑的设计标准提供化学和机械方面的见解。本文将特别关注水凝胶设计中涉及的化学方面:大分子单体的化学组成、交联策略和向“常规”及智能/刺激响应水凝胶的化学转化。本文还将考虑水凝胶的机械性能,以满足再生医学应用的需求。