National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
J Cell Biol. 2022 Oct 3;221(10). doi: 10.1083/jcb.202209004. Epub 2022 Sep 16.
Liquid-liquid phase separation (LLPS) triages protein cargoes for autophagic degradation. In this issue, Ohshima et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202203102) demonstrate that the autophagy receptor NCOA4 interacts with ferritin particles to form liquid-like condensates via LLPS. The NCOA4-ferritin condensates are delivered to lysosomes for degradation via either canonical macroautophagy or endosomal microautophagy to maintain intracellular iron homeostasis.
液-液相分离 (LLPS) 将蛋白质货物分类进行自噬降解。在本期杂志中，Ohshima 等人（2022. J. Cell Biol.https://doi.org/10.1083/jcb.202203102）证明，自噬受体 NCOA4 通过 LLPS 与铁蛋白颗粒相互作用形成液态凝聚物。NCOA4-铁蛋白凝聚物通过经典的巨自噬或内体微自噬递送至溶酶体进行降解，以维持细胞内铁的平衡。
