Kessler David A, Levine Herbert
Department of Physics, Bar-Ilan University, Ramat-Gan 52900, Israel.
Center for Theoretical Biological Physics and Departments of Physics and Bioengineering, Northeastern University, Boston, Massachusetts 02215, USA.
Phys Rev Lett. 2022 Sep 2;129(10):108101. doi: 10.1103/PhysRevLett.129.108101.
Drug persistence is a phenomenon by which a small percentage of cancer cells survive the presentation of targeted therapy by transitioning to a quiescent state. Eventually some of these persister cells can transition back to an active growing state and give rise to resistant tumors. Here we introduce a quantitative genetics approach to drug-exposed populations of cancer cells in order to interpret recent experimental data regarding inheritance of persister probability. Our results indicate that alternating periods of drug treatment and drug removal may not be an effective strategy for eliminating persisters.
药物持久性是一种现象，即一小部分癌细胞通过转变为静止状态而在靶向治疗下存活下来。最终，这些持久性细胞中的一些会转变回活跃的生长状态并产生耐药肿瘤。在这里，我们引入一种定量遗传学方法来研究暴露于药物的癌细胞群体，以便解释有关持久性概率遗传的最新实验数据。我们的结果表明，交替进行药物治疗和停药的时期可能不是消除持久性细胞的有效策略。
