Karadeniz Fatma Özpamuk, Sancaktepe Emine Altuntaş, Karadeniz Yusuf
Associate Prof, Faculty of Medicine, Department of Cardiology, 166263Karamanoğlu Mehmetbey University, Karaman, Turkey.
Department of Cardiology, 567570Professor Dr İlhan Varank Training and Research Hospital, İstanbul, Turkey.
Angiology. 2023 Feb;74(2):139-148. doi: 10.1177/00033197221124763. Epub 2022 Sep 16.
The triglyceride-glucose (TyG) index is calculated from fasting triglycerides and fasting glucose levels and is an indicator of insulin resistance. The present study investigates whether the TyG index has a role in predicting clinical outcomes in cases of acute coronary syndrome (ACS). This retrospective study included 646 patients with ST-elevation myocardial infarction (STEMI) and 1048 patients with non-ST-elevation myocardial infarction (NSTEMI). The association between major adverse cardiac events (MACEs) that developed in-hospital and at 60 months of follow-up and TyG index values were compared. Patients were divided into 2 groups: TyG index values of ≥8.65 and <8.65. During the hospital stay and 60 months of follow-up, 303 MACEs occurred. In both the STEMI and NSTEMI groups, as the TyG index increased, an increase was observed in MACE rates. MACE rates were also found to be highest in the group with TyG index ≥8.65 ( < .001). TyG index, C-reactive protein, and age were independent predictors of MACEs in both the NSTEMI and STEMI groups. The present study found a significant association between higher TyG index values and increased risk of MACEs in ACS patients. The TyG index may prove useful to predict clinical outcomes in ACS patients.
甘油三酯-葡萄糖（TyG）指数由空腹甘油三酯和空腹血糖水平计算得出，是胰岛素抵抗的一个指标。本研究调查TyG指数在预测急性冠状动脉综合征（ACS）病例临床结局方面是否起作用。这项回顾性研究纳入了646例ST段抬高型心肌梗死（STEMI）患者和1048例非ST段抬高型心肌梗死（NSTEMI）患者。比较了住院期间及随访60个月时发生的主要不良心脏事件（MACE）与TyG指数值之间的关联。患者被分为两组：TyG指数值≥8.65和＜8.65。在住院期间及随访60个月时，共发生303例MACE。在STEMI组和NSTEMI组中，随着TyG指数升高，MACE发生率均升高。还发现TyG指数≥8.65的组中MACE发生率最高（P＜0.001）。TyG指数、C反应蛋白和年龄是NSTEMI组和STEMI组中MACE的独立预测因素。本研究发现，较高的TyG指数值与ACS患者发生MACE的风险增加之间存在显著关联。TyG指数可能对预测ACS患者的临床结局有用。
