Zeng Qingyue, Zhong Qian, Zhao Lijun, An Zhenmei, Li Shuangqing
General Practice Medical Center, West China Hospital, General Practice Ward/International Medical Center Ward, National Clinical Research Center for Geriatrics,, Sichuan University, Chengdu, Sichuan, China.
Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Sci Rep. 2024 Dec 28;14(1):31092. doi: 10.1038/s41598-024-82305-x.
The triglyceride-glucose (TyG) index and the Atherogenic Index of Plasma (AIP) are both predictors of cardiovascular diseases (CVD). However, their combined and individual contributions to CVD risk are not well understood. This study evaluate the joint and individual associations of the TyG index and AIP with CVD events in middle-aged and older Chinese adults. This nationwide, retrospective cohort study utilized data from CHARLS. The diagnosis of CVD in this study was determined based on self-reported information provided by participants regarding their medical history( heart disease and/or stroke). Cross-sectional analyses in 2011 and longitudinal analyses over a 9-year follow-up were conducted to assess these associations. In the cross-sectional analysis, 8,531 participants were included at baseline. The odds ratio (OR) for TyG alone was 1.06 (95% CI 0.96-1.22) for CVD, while the OR for AIP alone was 1.16 (95% CI 1.02-1.33). Combined analysis showed that compared to the low TyG & low AIP group, the OR for the high TyG & high AIP group was 1.23 (95% CI 1.07-1.42) for CVD. In the survival Analysis, the hazard ratio (HR) for TyG alone was 1.19 (95% CI 1.04-1.35) for CVD, while the HR for AIP alone was 1.25 (95% CI 1.09-1.43). Combined analysis showed that compared to the low TyG & low AIP group, the HR for the high TyG & high AIP group was 1.27 (95% CI 1.10-1.43) for CVD. The findings underscore the significant coexposure effects of the TyG index and AIP on CVD, particularly in middle-aged adults.
甘油三酯-葡萄糖（TyG）指数和血浆致动脉粥样硬化指数（AIP）都是心血管疾病（CVD）的预测指标。然而，它们对CVD风险的联合和单独作用尚未得到充分了解。本研究评估了TyG指数和AIP与中国中老年成年人CVD事件的联合及个体关联。这项全国性的回顾性队列研究使用了中国健康与养老追踪调查（CHARLS）的数据。本研究中CVD的诊断基于参与者提供的关于其病史（心脏病和/或中风）的自我报告信息。进行了2011年的横断面分析以及为期9年随访的纵向分析来评估这些关联。在横断面分析中，基线时纳入了8531名参与者。单独TyG的CVD优势比（OR）为1.06（95%可信区间0.96 - 1.22），而单独AIP的OR为1.16（95%可信区间1.02 - 1.33）。联合分析显示，与低TyG和低AIP组相比，高TyG和高AIP组的CVD OR为1.23（95%可信区间1.07 - 1.42）。在生存分析中，单独TyG的CVD风险比（HR）为1.19（95%可信区间1.04 - 1.35），而单独AIP的HR为1.25（95%可信区间1.09 - 1.43）。联合分析显示，与低TyG和低AIP组相比，高TyG和高AIP组的CVD HR为1.27（95%可信区间1.10 - 1.43）。这些发现强调了TyG指数和AIP对CVD的显著共同暴露效应，尤其是在中年成年人中。
