Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.
Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.
J Photochem Photobiol B. 2022 Oct;235:112565. doi: 10.1016/j.jphotobiol.2022.112565. Epub 2022 Sep 9.
Photochemical instability and reactivity of organic ultraviolet (UV) filters not only degrade the performance of sunscreen formulations but also generate toxic photodegradation products and reactive oxygen species (ROS). Although the encapsulation of organic UV filters into synthetic polymer particles has been widely investigated, synthetic plastics were recently banned for personal care and cosmetic products due to marine and coastal pollution issues. Here we present a plastic-free, photochemically stable and inactive UV filter platform based on chitosan-coated mesoporous silica microparticles, denoted 'mSOCPs', incorporating octyl methoxycinnamate (OMC) as a sunscreen agent. Sunlight induced the degradation of ∼80% free OMC in artificial sweat in 1 h at room temperature, while only 20% of OMC degraded for 3 h when encapsulated within mSOCPs. Moreover, mSOCPs efficiently suppressed the photochemical generation of ROS by about 99% through the combined effects of the mesoporous silica structure and chitosan coating. Accordingly, mSOCPs substantially increased the cell viability of fibroblasts exposed to UV irradiation. This work demonstrates that the biopolymer coatings of mesoporous inorganic particles can be a promising approach to the plastic-free encapsulation of organic UV filters for suppressing their photochemical reactivity and degradation.
有机紫外线 (UV) 过滤器的光化学不稳定性和反应性不仅会降低防晒霜配方的性能，还会产生有毒的光降解产物和活性氧物质 (ROS)。尽管已经广泛研究了将有机 UV 过滤器封装到合成聚合物颗粒中，但由于海洋和沿海污染问题，最近已禁止将合成塑料用于个人护理和化妆品产品。在这里，我们提出了一种无塑料、光化学稳定且不活跃的基于壳聚糖涂覆的介孔二氧化硅微球的 UV 过滤器平台，称为“mSOCPs”，其中包含作为防晒剂的辛基甲氧基肉桂酸酯 (OMC)。在室温下，光照在人工汗中诱导约 80%的游离 OMC 在 1 小时内降解，而当封装在 mSOCPs 中时，OMC 在 3 小时内仅降解 20%。此外，mSOCPs 通过介孔硅结构和壳聚糖涂层的协同作用，有效地抑制了 ROS 的光化学生成，抑制率约为 99%。因此，mSOCPs 显著提高了暴露于紫外线照射下的成纤维细胞的细胞活力。这项工作表明，介孔无机颗粒的生物聚合物涂层可能是一种有前途的方法，可以实现无塑料封装有机 UV 过滤器，以抑制其光化学反应性和降解。
