Peter H J, Gerber H, Studer H, Becker D V, Peterson M E
J Clin Invest. 1987 Aug;80(2):491-8. doi: 10.1172/JCI113097.
Hyperthyroidism caused by nodular goiters is a common disease of aging cats. Growth and iodine metabolism were studied by autoradiography in normal and hyperfunctioning thyroid tissue obtained from cats injected with 125I before surgery, and in xenografts, grown in nude mice, after double-labeling with 131I and [3H]thymidine. Hyperthyroid cat goiters contain single or multiple hyperplastic nodules, consisting of highly cellular tissue with an iodine metabolism exceeding that of the surrounding normal tissue. Xenografts of hyperplastic hot tissue in thyroxine-treated nude mice retain their original histologic pattern and continue to accumulate radioiodine intensely. Autoradiographs assessed for [3H]thymidine incorporation reveal autonomously proliferating follicular cells within the hyperplastic foci but not within the normal tissue. Administration of sera from donor cats into host mice fails to stimulate the xenografts. Neither hyperfunction nor growth of toxic cat goiters depends on extrathyroidal stimulators. The basic lesion appears to be an excessive intrinsic growth capacity of some thyroid cells.
结节性甲状腺肿引起的甲状腺功能亢进是老年猫的常见疾病。通过放射自显影研究了生长和碘代谢，这些研究涉及术前注射125I的猫所获取的正常和功能亢进甲状腺组织，以及用131I和[3H]胸腺嘧啶核苷进行双重标记后在裸鼠体内生长的异种移植物。甲状腺功能亢进的猫甲状腺肿含有单个或多个增生性结节，由细胞高度密集的组织构成，其碘代谢超过周围正常组织。经甲状腺素处理的裸鼠体内增生性热结节的异种移植物保持其原始组织学模式，并继续强烈积聚放射性碘。评估[3H]胸腺嘧啶核苷掺入情况的放射自显影片显示，增生灶内的滤泡细胞自主增殖，但正常组织内的滤泡细胞无此现象。将供体猫的血清注入宿主小鼠未能刺激异种移植物。毒性猫甲状腺肿的功能亢进和生长均不依赖于甲状腺外刺激物。基本病变似乎是某些甲状腺细胞内在生长能力过度。
