狗体内前列环素（PGI2）的再循环
Recirculation of prostacyclin (PGI2) in the dog.
作者信息
Dusting G J, Moncada S, Vane J R
出版信息
Br J Pharmacol. 1978 Oct;64(2):315-20. doi: 10.1111/j.1476-5381.1978.tb17307.x.
Abstract
1 The inactivation of prostacyclin (PGI2) in the circulation of anaesthetized dogs has been studied by the blood-bathed organ bioassay technique. 2 Spiral strips of bovine coronary and rabbit coeliac or mesenteric artery detected concentrations of PGI2 of 2 to 5 ng/ml. These tissues were insensitive to concentrations at least 200 fold higher of 15-oxo-PGI2 and 6-oxo-PGF1alpha. 3 PGI2 assayed on bovine coronary artery, rabbit coeliac artery or rat stomach strip, had a half life in blood of 3.0 +/- 0.3 min, indicating non-enzymatic degradation. 4 No disappearance could be detected by bovine coronary artery when PGI2 was infused across the lungs (0.1 to 0.5 microgram kg-1 min-1). However, PGI2 was partially inactivated in passage through vascular beds of hindquarters and liver. 5 Of PGI2 infused into the aorta 35 to 65% escaped inactivation in one complete circulation. Therefore, endogenous PGI2 released from the lungs may function as a circulating hormone.
摘要
- 采用血浴器官生物测定技术研究了麻醉犬循环中前列环素（PGI2）的失活情况。2. 牛冠状动脉及兔腹腔或肠系膜动脉的螺旋条能检测到浓度为2至5 ng/ml的PGI2。这些组织对浓度至少高出200倍的15-氧代-PGI2和6-氧代-PGF1α不敏感。3. 在牛冠状动脉、兔腹腔动脉或大鼠胃条上测定，PGI2在血液中的半衰期为3.0±0.3分钟，表明其为非酶促降解。4. 当以0.1至0.5微克·千克-1·分钟-1的速率经肺灌注PGI2时，牛冠状动脉未检测到其消失。然而，PGI2在通过后肢和肝脏的血管床时会部分失活。5. 注入主动脉的PGI2在一次完整循环中有35%至65%未被失活。因此，从肺释放的内源性PGI2可能作为一种循环激素发挥作用。
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