Palonek E, Korbut R, Gryglewska T, Gryglewski R J
Prostaglandins. 1980 Dec;20(6):993-1006. doi: 10.1016/0090-6980(80)90054-4.
Isolated perfused cat lungs secreted spontaneously a PGI2-like substance that relaxed a strip of bovine coronary artery. The presence of PGI2 was confirmed by the identification of 6-oxo-PGF1 alpha by GC-MS. Both bioassay and mass fragmentography showed that PGI2 was released at a rate of 4 - 12 ng/ml. Generation of PGI2 by the perfused cat lungs was stimulated by angiotensin II (3 - 10 ng/ml). The above results along with our in vivo experiments point to the lung as an important source of endogenous PGI2 in the body.
离体灌注的猫肺可自发分泌一种类似前列环素（PGI2）的物质，该物质能使一条牛冠状动脉条带舒张。通过气相色谱 - 质谱法鉴定6 - 氧代 - PGF1α证实了PGI2的存在。生物测定和质谱分析均表明PGI2的释放速率为4 - 12纳克/毫升。血管紧张素II（3 - 10纳克/毫升）可刺激灌注的猫肺生成PGI2。上述结果以及我们的体内实验表明，肺是体内内源性PGI2的重要来源。
