Moore J K, Moore R Y
J Comp Neurol. 1987 Jun 8;260(2):157-74. doi: 10.1002/cne.902600202.
The distribution of GABA-producing neurons in the brainstem auditory nuclei of the rat was investigated immunohistochemically by using an antibody to glutamic acid decarboxylase (GAD). In the cochlear nuclei, GAD immunoreactive neurons are present only in the superficial granular and molecular layers, whereas terminals are found in all subdivisions of the nuclei and are particularly dense surrounding large spherical cells and one type of stellate cell. In the superior olivary complex, GAD immunoreactive neurons are located in the lateral olivary nucleus and throughout the periolivary region. Immunoreactive terminals are distributed along dendrites of principal cells of the medial and lateral olivary nuclei and are clustered around somata of globular neurons of the nucleus of the trapezoid body. An extremely dense band of immunoreactive somata and terminals is present along the ventral edge of the olivary complex. The ventral, intermediate, and dorsal nuclei of the lateral lemniscus contain small fusiform GAD-immunoreactive neurons and a moderately dense plexus of immunoreactive terminals. The inferior colliculus contains a large population of GAD-immunoreactive perikarya and an extremely dense accumulation of immunoreactive terminals in the central, dorsomedial, and external nuclei. These observations indicate that GABA systems are involved in function at all levels of the brainstem auditory pathway.
利用谷氨酸脱羧酶（GAD）抗体，通过免疫组织化学方法研究了大鼠脑干听觉核中产生γ-氨基丁酸（GABA）的神经元的分布。在耳蜗核中，GAD免疫反应性神经元仅存在于浅层颗粒层和分子层，而终末见于该核的所有亚区，并且在大球形细胞和一种星形细胞周围特别密集。在上橄榄复合体中，GAD免疫反应性神经元位于外侧橄榄核和整个橄榄周区域。免疫反应性终末沿内侧和外侧橄榄核主细胞的树突分布，并聚集在梯形体核球状神经元的胞体周围。沿着橄榄复合体的腹侧边缘存在一条极其密集的免疫反应性胞体和终末带。外侧丘系的腹侧核、中间核和背侧核含有小的梭形GAD免疫反应性神经元以及中等密集的免疫反应性终末丛。下丘在中央核、背内侧核和外侧核中含有大量GAD免疫反应性核周体以及极其密集的免疫反应性终末聚集。这些观察结果表明，GABA系统参与脑干听觉通路各级的功能。
