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高压氧:医学研究委员会的试验及其临床意义。

Hyperbaric oxygen: the Medical Research Council trials and their clinical significance.

作者信息

Dische S

出版信息

Br J Radiol. 1978 Nov;51(611):888-94. doi: 10.1259/0007-1285-51-611-888.

DOI:10.1259/0007-1285-51-611-888
PMID:361145
Abstract

The clinical trials of the use of hyperbaric oxygen in radiotherapy conducted by the Medical Research Council's working party have shown that local cure and survival can be improved in head and neck and cervical cancer. Evidence for benefit has been presented in carcinoma of bronchus, but none has so far been found in carcinoma of the bladder. Although hyperbaric oxygen has produced increased effect upon normal tissues as well as upon tumour, a real improvement in therapeutic ratio appears to be present. The future use of hyperbaric oxygen in radiotherapy will depend upon a comparison of effectiveness with other methods now being tested to improve radiotherapy. The trials have yielded much fundamental and clinical data of general relevance in the radiotherapy of malignant disease.

摘要

医学研究委员会工作组进行的关于高压氧在放射治疗中应用的临床试验表明,头颈部癌和宫颈癌的局部治愈率和生存率可以得到提高。在支气管癌中已呈现出获益证据,但目前在膀胱癌中尚未发现。尽管高压氧对正常组织和肿瘤都产生了增强作用,但治疗比似乎确实有所改善。高压氧在放射治疗中的未来应用将取决于与目前正在测试的其他改善放射治疗方法的有效性比较。这些试验已经产生了许多与恶性疾病放射治疗普遍相关的基础和临床数据。

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Hyperbaric oxygen: the Medical Research Council trials and their clinical significance.高压氧:医学研究委员会的试验及其临床意义。
Br J Radiol. 1978 Nov;51(611):888-94. doi: 10.1259/0007-1285-51-611-888.
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