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高压氧与放射治疗:医学研究委员会关于宫颈癌的一项试验

Hyperbaric oxygen and radiotherapy: a Medical Research Council trial in carcinoma of the cervix.

作者信息

Watson E R, Halnan K E, Dische S, Saunders M I, Cade I S, McEwen J B, Wiernik G, Perrins D J, Sutherland I

出版信息

Br J Radiol. 1978 Nov;51(611):879-87. doi: 10.1259/0007-1285-51-611-879.

DOI:10.1259/0007-1285-51-611-879
PMID:361144
Abstract

In a randomized controlled clinical trial of hyperbaric oxygen in the radiotherapy of advanced carcinoma of the uterine cervix a total of 320 cases were contributed by four radiotherapy centres in the United Kingdom. The use of hyperbaric oxygen resulted in improved local control and survival. The benefit was greatest in patients under the age of 55 who presented with stage III disease. There was a slight increase in radiation morbidity but it seemed that the benefit of hyperbaric oxygen outweighed this increase in morbidity and that there was a true improvement in the therapeutic ratio.

摘要

在一项关于高压氧用于晚期宫颈癌放射治疗的随机对照临床试验中,英国四个放射治疗中心共提供了320例病例。使用高压氧可改善局部控制和生存率。对于年龄在55岁以下、患有III期疾病的患者,益处最大。放射治疗的发病率略有增加,但高压氧的益处似乎超过了发病率的增加,并且治疗比率有了真正的提高。

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Hyperbaric oxygen and radiotherapy: a Medical Research Council trial in carcinoma of the cervix.高压氧与放射治疗:医学研究委员会关于宫颈癌的一项试验
Br J Radiol. 1978 Nov;51(611):879-87. doi: 10.1259/0007-1285-51-611-879.
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Radiotherapy and hyperbaric oxygen. Report of a Medical Research Council Working Party.放射疗法与高压氧。医学研究委员会工作小组报告。
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Hyperbaric oxygen: the Medical Research Council trials and their clinical significance.高压氧:医学研究委员会的试验及其临床意义。
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Int J Radiat Oncol Biol Phys. 1981 Aug;7(8):991-8. doi: 10.1016/0360-3016(81)90149-8.

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