Effect of bisphenol F on sexual performance and quality of offspring in Male Wistar rats.

This study investigated the effect of BPF on male sexual performance and the quality of the offspring. Eighty (80) Male Wistar rats (n = 10 per group) were randomised into normal saline-treated control and control recovery, BPF varied doses (low, medium, and high), and BPF varied doses recovery (low, medium, and high) groups. The study was terminated after 28 days of BPF oral administration. The animals were sacrificed after 24 h from the last dose, while those in the recovery groups were allowed to recover for another 28 days before being sacrificed. BPF administration was found to impair sexual performance, as shown by a significant decrease in frequencies (mount, intromission, and ejaculation frequencies) and an increase in latencies (mount, intromission, and ejaculation latencies). This was accompanied by a significant decrease in plasma LH, FSH, testosterone, dopamine, acetylcholinesterase, nitric oxide, and penile cyclic guanosine monophosphate (cGMP) level. The level of plasma oestrogen and prolactin were significantly increased following BPF administration. BPF also reduced the sperm count, morphology, viability, and motility. Furthermore, BPF reduced fertility success and index, litter size, litter weight, and offspring survival rate. These toxic effects of BPF were dose-dependent and were not reversed by withdrawal following 28 days of recovery. This study concluded that BPF disrupts sexual competence and offspring quality by suppressing the hypothalamic-pituitary-gonadal axis and mediating oestrogen-induced hyperprolactinemia. These events were associated with reduced fertility index and success, poor semen quality, and reduced offspring survival rate. The observed toxic effects of BPF were dose-dependent and not reversed by cessation of BPF exposure.