Odetayo Adeyemi Fatai, Hamed Moses Agbomhere, Bassey Grace Edet, Titiloye Oluranti Olayinka, Maduabuchi Samson Daniel, Okesina Kazeem Bidemi, Olayaki Luqman Aribidesi
Department of Physiology, Faculty of Basic Medical Sciences, Federal University of Health Sciences, Ila-Orangun, Nigeria.
Endocrinology, Reproductive, and Metabolism Unit, Physiology Department, Federal University of Health Sciences, Ila-Orangun, Nigeria.
Biochem Biophys Rep. 2025 Jun 23;43:102103. doi: 10.1016/j.bbrep.2025.102103. eCollection 2025 Sep.
Bisphenol F (BPF) is an established environmental pollutant that has been shown to distort erectile function. However, the effect of BPF on penile redox homeostasis is not known. On the other hand, omega-3 fatty acids (O3FA) are known antioxidants with fertility-enhancing properties. Despite these abilities, the ameliorative effect of O3FA on BPF-induced penile redox imbalance is unknown. Hence, this study was designed to add to the existing body of knowledge by investigating the role of penile redox homeostasis on BPF-induced erectile dysfunction and the possible ameliorative effect of O3FA.
Twenty male Wistar rats were randomly divided into four groups (n = 5/group) after two weeks acclimatization period as follows: control group (.5 ml of corn oil), O3FA group (300mg/kg of O3FA), BPF group (30mg/kg of BPF), and the BPF + O3FA group (30 mg/kg of BPF + 300mg/kg of O3FA).
BPF exposure led to sexual and erectile dysfunction, which was accompanied by a disruption in erectogenic enzymatic activities and circulatory testosterone. These events were accompanied by the down-regulation of penile NO/cGMP signaling, oxido-inflammatory response, and penile histoarchitecture distortion. These observed BPF-induced distortions were ameliorated in animals that received O3FA co-treatment with BPF.
BPF-induced erectile dysfunction was associated with penile redox imbalance, and O3FA ameliorated BPF-induced penile toxicity.
双酚F（BPF）是一种已被确认的环境污染物，已被证明会干扰勃起功能。然而，BPF对阴茎氧化还原稳态的影响尚不清楚。另一方面，ω-3脂肪酸（O3FA）是已知的具有生育增强特性的抗氧化剂。尽管有这些作用，但O3FA对BPF诱导的阴茎氧化还原失衡的改善作用尚不清楚。因此，本研究旨在通过研究阴茎氧化还原稳态在BPF诱导的勃起功能障碍中的作用以及O3FA可能的改善作用，来增加现有知识体系。
20只雄性Wistar大鼠在经过两周的适应期后，随机分为四组（每组n = 5），如下：对照组（0.5毫升玉米油）、O3FA组（300毫克/千克O3FA）、BPF组（30毫克/千克BPF）和BPF + O3FA组（30毫克/千克BPF + 300毫克/千克O3FA）。
暴露于BPF会导致性功能和勃起功能障碍，同时伴有勃起相关酶活性和循环睾酮的紊乱。这些情况还伴随着阴茎一氧化氮/环磷酸鸟苷信号通路的下调、氧化炎症反应以及阴茎组织结构的扭曲。在接受O3FA与BPF联合治疗的动物中，这些观察到的BPF诱导的扭曲得到了改善。
BPF诱导的勃起功能障碍与阴茎氧化还原失衡有关，O3FA改善了BPF诱导的阴茎毒性。
