Department of Public Health, Research Unit for Epidemiology, Aarhus University, 8000 Aarhus, Denmark.
Department of Urology, Regional Hospital of West Jutland, 7500 Holstebro, Denmark.
Int J Environ Res Public Health. 2021 Feb 11;18(4):1742. doi: 10.3390/ijerph18041742.
Bisphenol A (BPA) is considered an endocrine disruptor and has been associated with deleterious effects on spermatogenesis and male fertility. Bisphenol F (BPF) and S (BPS) are structurally similar to BPA, but knowledge of their effects on male fertility remains limited. In this cross-sectional study, we investigated the associations between exposure to BPA, BPF, and BPS and semen quality in 556 men 18-20 years of age from the Fetal Programming of Semen Quality (FEPOS) cohort. A urine sample was collected from each participant for determination of BPA, BPF, and BPS concentrations while a semen sample was collected to determine ejaculate volume, sperm concentration, total sperm count, sperm motility, and sperm morphology. Associations between urinary bisphenol levels (continuous and quartile-divided) and semen characteristics were estimated using a negative binomial regression model adjusting for urine creatinine concentration, alcohol intake, smoking status, body mass index (BMI), fever, sexual abstinence time, maternal pre-pregnancy BMI, and first trimester smoking, and highest parental education during first trimester. We found no associations between urinary bisphenol of semen quality in a sample of young men from the general Danish population.
双酚 A（BPA）被认为是一种内分泌干扰物，与精子发生和男性生育力的有害影响有关。双酚 F（BPF）和 S（BPS）在结构上与 BPA 相似，但它们对男性生育力的影响知之甚少。在这项横断面研究中，我们调查了暴露于 BPA、BPF 和 BPS 与来自精液质量胎儿编程（FEPOS）队列的 556 名 18-20 岁男性精液质量之间的关联。从每个参与者收集尿液样本以确定 BPA、BPF 和 BPS 浓度，同时收集精液样本以确定精液量、精子浓度、总精子数、精子活力和精子形态。使用负二项回归模型估计尿液中双酚水平（连续和四分位数划分）与精液特征之间的关联，该模型调整了尿肌酐浓度、酒精摄入量、吸烟状况、体重指数（BMI）、发热、禁欲时间、母亲孕前 BMI 和孕早期吸烟以及孕早期最高父母教育。我们在来自丹麦普通人群的年轻男性样本中没有发现尿液双酚与精液质量之间的关联。
