State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, PR China; MIIT Key Laboratory of Multifunctional Lightweight Materials and Structures, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, PR China.
State Key Laboratory of Mechanics and Control of Mechanical Structures, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, PR China; MIIT Key Laboratory of Multifunctional Lightweight Materials and Structures, Nanjing University of Aeronautics and Astronautics, Nanjing, 210016, PR China.
J Mech Behav Biomed Mater. 2022 Nov;135:105432. doi: 10.1016/j.jmbbm.2022.105432. Epub 2022 Sep 2.
Blockage of ureter caused by kidney stone, accompanied by severe pain/infections, is a high incidence urinary tract disease that has received extensive attention. Currently, in clinics, a kidney stone with diameter less than ∼5 mm is considered capable of passing through ureter. However, this critical size (∼5 mm) is empirically based, lacking quantitative analysis. In this study, we proposed a stone-ureter interaction model to quantificationally estimate the critical size of kidney stone passing through ureter. We revealed that the critical size of kidney stone is related to ureter size, about 11%-22% larger than the inner diameter of ureter. Further, based upon the Winkler elastic foundation beam model, we developed a simplified stone-ureter interaction model to evaluate how this critical size is dependent upon the stiffness of ureter and the surface roughness of kidney stone. The proposed model may help urologists improve the accuracy of personalized diagnosis and treatment.
肾结石导致的输尿管阻塞，伴有严重疼痛/感染，是一种高发的尿路疾病，受到广泛关注。目前，在临床上，直径小于∼5 毫米的肾结石被认为能够通过输尿管。然而，这个关键尺寸（∼5 毫米）是基于经验的，缺乏定量分析。在这项研究中，我们提出了一种结石-输尿管相互作用模型，以定量估计肾结石通过输尿管的关键尺寸。我们揭示了肾结石的关键尺寸与输尿管的尺寸有关，大约比输尿管的内径大 11%-22%。此外，基于文克勒弹性基础梁模型，我们开发了一个简化的结石-输尿管相互作用模型，以评估这个关键尺寸如何依赖于输尿管的刚度和肾结石的表面粗糙度。所提出的模型可以帮助泌尿科医生提高个性化诊断和治疗的准确性。
