Beierle Andee M, Quinn Colin H, Markert Hooper R, Carr Adam, Marayati Raoud, Bownes Laura V, Hutchins Sara Claire, Stewart Jerry E, Hill Benjamin, Ohlmeyer Michael, Reuel Nigel F, Beierle Elizabeth A
Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham, Alabama 35233, United States.
Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama 35233, United States.
ACS Omega. 2022 Sep 2;7(36):32690-32700. doi: 10.1021/acsomega.2c04345. eCollection 2022 Sep 13.
Cancer continues to be a significant cause of non-traumatic pediatric mortality. Diagnosis of pediatric solid tumors is paramount to prescribing the correct treatment regimen. Recent efforts have focused on non-invasive methods to obtain tumor tissues, but one of the challenges encountered is the ability to obtain an adequate amount of viable tissue. In this study, a wireless, inductor-capacitor (LC) sensor was employed to detect relative permittivity of pediatric tumor tissues. There is a comparison of resonant frequencies of tumor tissues between live versus dead tissues, the primary tumor tissue versus tissue from the organs of origin or metastasis, and treated versus untreated tumors. The results show significant shifts in resonant frequencies between the comparison groups. Dead tissues demonstrated a significant shift in resonant frequencies compared to alive tissues. There were significant differences between the resonant frequencies of normal tissues versus tumor tissues. Resonant frequencies were also significantly different between primary tumors compared to their respective metastases. These data indicate that there are potential clinical applications of LC technology in the detection and diagnosis of pediatric solid tumors.
癌症仍然是儿童非创伤性死亡的一个重要原因。小儿实体瘤的诊断对于制定正确的治疗方案至关重要。最近的努力集中在获取肿瘤组织的非侵入性方法上，但遇到的挑战之一是能否获得足够数量的活组织。在本研究中，采用了一种无线电感电容（LC）传感器来检测小儿肿瘤组织的相对介电常数。对活组织与死组织、原发性肿瘤组织与来自原发器官或转移器官的组织以及治疗后与未治疗的肿瘤之间的肿瘤组织共振频率进行了比较。结果显示比较组之间的共振频率有显著变化。与活组织相比，死组织的共振频率有显著变化。正常组织与肿瘤组织的共振频率存在显著差异。原发性肿瘤与其各自转移灶的共振频率也有显著差异。这些数据表明LC技术在小儿实体瘤的检测和诊断中具有潜在的临床应用价值。
