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既往新冠病毒病诊断对全关节置换术并发症发生率无影响。

Prior Diagnosis of COVID Has No Increased Complications in Total Joint Arthroplasty.

作者信息

Lung Brandon E, Taka Taha M, Donnelly Megan, McLellan Maddison, Callan Kylie, Issagholian Leo, Lai Wilson, So David, McMaster William, Yang Steven

机构信息

Orthopedic Surgery, University of California, Irvine, Irvine, USA.

Orthopedic Surgery, University of California, Riverside, Riverside, USA.

出版信息

Cureus. 2022 Aug 13;14(8):e27974. doi: 10.7759/cureus.27974. eCollection 2022 Aug.

Abstract

Introduction Although a substantial portion of the United States population has been infected with and recovered from Coronavirus Disease-19 (COVID-19), many patients may have persistent symptoms and complications from disease-driven respiratory disease, arrhythmias, and venous thromboembolism (VTE). With institutions resuming elective total joint arthroplasties (TJA), it is unclear whether a prior resolved diagnosis of COVID has any implications on postoperative outcomes. Methods All elective TJA performed in 2021 at our institution were retrospectively reviewed and a history of prior COVID+ result recorded. Baseline demographics, days from prior COVID+ result to surgery date, preoperative methicillin-resistant Staphylococcus aureus (MRSA) nares colonization, and laboratory markers were obtained to determine baseline characteristics. Postoperative estimated blood loss (EBL), length of stay (LOS), rate of revision surgery, and discharge destination were compared between groups. Perioperative and postoperative rates of VTE, urinary tract infection (UTI), pneumonia, postoperative oxygen supplementation, cardiac arrhythmia, renal disease, sepsis, and periprosthetic joint infections within six months of surgery were recorded. Results Of the 155 elective TJA performed in 2021, 24 patients had a prior COVID+ diagnosis with a mean of 253 days from positive result to surgery date. There were no significant differences in baseline demographics, comorbidities, and preoperative lab markers between groups. Surgeries on patients with a prior COVID+ had a significantly higher EBL (260 vs 175cc), but postoperative outcomes of VTE, UTI, pneumonia, oxygen supplementation requirement, nares MRSA+, cardiac disease, and infection rates between groups were similar. Bivariate logistic regression revealed increased days from COVID+ diagnosis (>6 months) to surgery date were associated with a shorter LOS. Conclusion Although a prior COVID+ diagnosis had increased intraoperative blood loss, there were no significant differences in respiratory, infectious, cardiac, and thromboembolic complications up to six months after elective TJA. This study suggests that asymptomatic C+ patients receiving elective TJA do not require more aggressive prophylactic anticoagulation or antibiotic regimens to prevent VTE or perioperative infections. As institutions around the nation resume pre-COVID rates of arthroplasty surgeries, a prior diagnosis of COVID appears to have no effects on postoperative complications.

摘要

引言 尽管美国很大一部分人口已感染新型冠状病毒肺炎(COVID-19)并康复,但许多患者可能仍有持续性症状以及由疾病引发的呼吸道疾病、心律失常和静脉血栓栓塞(VTE)等并发症。随着各医疗机构恢复择期全关节置换术(TJA),既往确诊的COVID-19是否会对术后结果产生影响尚不清楚。方法 对2021年在我院进行的所有择期TJA进行回顾性研究,并记录既往COVID检测呈阳性的病史。收集基线人口统计学数据、从既往COVID检测呈阳性结果到手术日期的天数、术前耐甲氧西林金黄色葡萄球菌(MRSA)鼻腔定植情况以及实验室指标,以确定基线特征。比较两组患者的术后估计失血量(EBL)、住院时间(LOS)、翻修手术率和出院去向。记录手术围术期和术后6个月内的VTE、尿路感染(UTI)、肺炎、术后吸氧、心律失常、肾病、脓毒症和假体周围关节感染发生率。结果 2021年进行的155例择期TJA中,24例患者既往COVID检测呈阳性,从阳性结果到手术日期的平均时间为253天。两组患者在基线人口统计学、合并症和术前实验室指标方面无显著差异。既往COVID检测呈阳性患者的手术EBL显著更高(260 vs 175cc),但两组之间VTE、UTI、肺炎、吸氧需求、鼻腔MRSA阳性、心脏病和感染率的术后结果相似。二元逻辑回归显示,从COVID检测呈阳性诊断(>6个月)到手术日期的天数增加与住院时间缩短相关。结论 尽管既往COVID检测呈阳性诊断会增加术中失血量,但在择期TJA术后6个月内,呼吸、感染、心脏和血栓栓塞并发症方面无显著差异。本研究表明,接受择期TJA的无症状COVID阳性患者不需要更积极的预防性抗凝或抗生素方案来预防VTE或围术期感染。随着全国各医疗机构恢复COVID疫情前的关节置换手术率,既往COVID诊断似乎对术后并发症没有影响。

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