Department of Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
University Hospital, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
AIDS Care. 2023 Dec;35(12):1821-1829. doi: 10.1080/09540121.2022.2119468. Epub 2022 Sep 17.
Availability of effective antiretroviral therapy (ART) has improved patient survival and older adults (≥50 years old) constitute 10% of the world's HIV population. However, data on this population are lacking, especially in sub-Saharan Africa. To identify the profile of older adults with HIV infection receiving ART and factors associated with viral suppression. A retrospective cross-sectional study involving HIV patients ≥50 years, registered at a University Hospital in Kumasi, Ghana from January 2010 to July 2020. All study participants had been on ARTs for ≥12 months. Data were analysed using STATA and multivariate logistic regression was done to determine the association between variables. We recruited 132 study participants with a mean age of 58.1 years (±6.8). Non-communicable diseases (NCD) comprised the commonest comorbidity (67.4%; = 89) and hypertension was the most prevalent (47.2%). The mean duration of ART was 63.2 months (±32.0) and approximately 84.1% ( = 111) achieved viral suppression (≤50 copies/ml). After adjustment, factors independently associated with viral suppression were widow(ed) (aOR = 0.23; 95% CI = 0.07-0.72) and good ART adherence (aOR = 3.51; 95% CI = 1.03-11.99). Hypertension is prevalent among this cohort of HIV patients. Approximately 84% of elderly patients on ARTs achieve viral suppression, influenced by widowhood and good drug adherence.
有效的抗逆转录病毒疗法(ART)的出现提高了患者的生存率,年龄在 50 岁及以上的成年人占世界艾滋病毒感染者的 10%。然而,关于这一人群的数据很少,尤其是在撒哈拉以南非洲。本研究旨在确定接受 ART 的老年艾滋病毒感染者的特征,以及与病毒抑制相关的因素。这是一项回顾性的横断面研究,涉及加纳库马西一所大学医院 2010 年 1 月至 2020 年 7 月期间年龄在 50 岁及以上的艾滋病毒患者。所有研究参与者均接受 ART 治疗≥12 个月。使用 STATA 分析数据,并进行多变量逻辑回归以确定变量之间的关联。我们共招募了 132 名研究参与者,平均年龄为 58.1 岁(±6.8)。非传染性疾病(NCD)是最常见的合并症(67.4%,89 例),高血压是最常见的合并症(47.2%)。ART 的平均持续时间为 63.2 个月(±32.0),约 84.1%(111 例)达到病毒抑制(≤50 拷贝/ml)。调整后,与病毒抑制独立相关的因素是丧偶(aOR=0.23;95%CI=0.07-0.72)和良好的 ART 依从性(aOR=3.51;95%CI=1.03-11.99)。高血压在这组艾滋病毒患者中很常见。约 84%的接受 ART 治疗的老年患者实现了病毒抑制,这受丧偶和良好药物依从性的影响。