Departamento Materno-infantil, Unidad de Trasplante de Médula Ósea, Fundación Valle del Lili, Cali, Colombia; Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia.
Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia; Departamento de Psiquiatría, Fundación Valle del Lili, Cali, Colombia.
Biomedica. 2022 Sep 2;42(3):531-540. doi: 10.7705/biomedica.6403.
Introduction: Hematopoietic stem cell transplantation is the curative option for some diseases and is increasing patient survival. The health-related quality of life in these patients is not systematically evaluated. Objectives: The present study sought to describe the health-related quality of life and complications in children who underwent hematopoietic stem cell transplantation. Materials and methods: A cross-sectional study was conducted on pediatric transplanted survivors. Health-related quality of life was measured using the KIDSCREEN-27 scale and Short Form-12 (SF-12) in patients between 8 and 14 years of age and those over 14 years, respectively. Statistical analysis was performed using STATA 12 software. We used the Rasch model person parameter estimates translated into T-values to score the questionnaire. Results: A total of 42 children answered the questionnaires. The most frequent adverse events were chronic graft Vs. host disease and endocrine complications. According to European norm data in the KIDSCREEN-12 scale, scores for the school dimension and social and peer support were below the 50th. percentile. The group administered immunosuppressants had lower scores on the physical component of the SF-12™ scale. Conclusions: In general, the KIDSCREEN-27 does appear to suggest some quality-of-life deficit in younger children. The scales showed reliability in this population.
造血干细胞移植是某些疾病的治疗选择，可以提高患者的生存率。这些患者的健康相关生活质量并未得到系统评估。目的：本研究旨在描述接受造血干细胞移植的儿童的健康相关生活质量和并发症。材料和方法：对接受过移植的儿科幸存者进行了一项横断面研究。使用 KIDSCREEN-27 量表和 Short Form-12（SF-12）分别评估 8 至 14 岁和 14 岁以上患者的健康相关生活质量。使用 STATA 12 软件进行统计分析。我们使用 Rasch 模型个人参数估计值转换为 T 值来对问卷进行评分。结果：共有 42 名儿童回答了问卷。最常见的不良事件是慢性移植物抗宿主病和内分泌并发症。根据 KIDSCREEN-12 量表的欧洲标准数据，学校维度和社会及同伴支持的得分低于第 50 个百分位。接受免疫抑制剂治疗的组在 SF-12TM 量表的生理成分上的得分较低。结论：总体而言，KIDSCREEN-27 似乎确实表明年龄较小的儿童存在一些生活质量缺陷。该量表在该人群中具有可靠性。
