Kuruc A, Treves S T, Rosen P R, Greenberg D
J Nucl Med. 1987 Aug;28(8):1338-40.
Quantitative analysis of the radionuclide renogram requires an estimate of the plasma time-activity curve. This estimate is usually obtained from an externally detected blood-pool curve that is calibrated with a single plasma sample. However, external probes detect activity in the extravascular as well as the intravascular space. This may lead to significant errors in estimating the plasma time-activity curve. A method for overcoming this problem by using a continuously varying calibration factor based upon multiple plasma samples was therefore evaluated. Externally detected blood-pool curves were used to estimate the plasma time-activity curves obtained from rabbits during radionuclide renography. Estimates obtained using the externally detected curves calibrated with a constant calibration factor were found to be significantly biased, while estimates obtained using the externally detected curves calibrated with the continuously varying calibration factor were not.
放射性核素肾图的定量分析需要估算血浆时间-活性曲线。这种估算通常从通过单个血浆样本校准的外部检测血池曲线获得。然而，外部探头检测血管外和血管内空间的活性。这可能导致在估算血浆时间-活性曲线时出现显著误差。因此，评估了一种基于多个血浆样本使用连续变化校准因子来克服此问题的方法。在放射性核素肾造影期间，使用外部检测的血池曲线来估算从兔子获得的血浆时间-活性曲线。发现使用恒定校准因子校准的外部检测曲线获得的估算存在显著偏差，而使用连续变化校准因子校准的外部检测曲线获得的估算则没有偏差。
