Chen H J, Fu L L, Fu Q Q, Xu X L, Wu W Y, Dai G M, Liu T, Zeng D G, Huang W Y, Chen F
Department of Radiology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou 570311, China.
Department of Radiology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou 570311, China.
Zhonghua Yi Xue Za Zhi. 2022 Sep 20;102(35):2763-2768. doi: 10.3760/cma.j.cn112137-20220705-01487.
To investigate the dynamic characteristics of brain spontaneous activity in betel quid dependence (BQD) chewers and its relationship with clinical indexes. This study was conducted in Hainan General Hospital from April to December 2019 and the data of 53 BQD chewers (37 males and 16 females, aged 20 to 58(38±11) years) and 37 healthy controls (HC) (24 males and 13 females, aged 23-57(42±12) years) were collected. All these subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI) scan. The dynamic characteristics of resting fMRI indexes, including dynamic amplitude of low-frequency fluctuations (ALFF), regional homogeneity (ReHo) and degree centrality (DC) of these subjects were calculated using the sliding time window method, parameters such as age and dynamic local consistency were analyzed and compared between the two groups. Pearson correlation was used to analyze the relationship between dynamic indexes, betel quid dependence score (BQDS) and disease duration in BQD group. BQD chewers showed decreased dynamic ALFF in the left orbital prefrontal cortex (0.138±0.041 vs 0.171±0.070), the right temporal pole superior temporal gyrus (0.277±0.070 vs 0.319±0.086) and the right inferior parietal lobule (0.223±0.052 vs 0.259±0.088) than HC (all <0.05). For regional homogeneity, BQD chewers showed a decrease dynamic ReHo in the right inferior temporal gyrus (0.055±0.008 vs 0.061±0.009), the orbital prefrontal cortex (0.058±0.005 vs 0.063±0.008), the right inferior frontal gyrus (0.081±0.006 vs 0.087±0.011), the right superior occipital gyrus (0.056±0.007 vs 0.062±0.008), the left precentral gyrus (0.068±0.008 vs 0.074±0.008), and the left superior frontal gyrus (0.058±0.008 vs 0.064±0.009) than HC (all <0.05). BQD chewers showed an increase dynamic ReHo in the right precuneus (0.095±0.009 vs 0.089±0.008) (<0.05). There was no significant difference in DC between the two groups (all >0.05). The relationships between three dynamic ALFF and BQDS (=-0.104, -0.015, -0.119), seven dynamic ReHo and BQDS (=-0.099, -0.141, -0.055, -0.078, -0.027, -0.111, -0.090), three dynamic ALFF and disease duration (=-0.122, -0.095, -0.171), and seven dynamic ReHo and disease duration (=0.242, -0.252, 0.035, 0.056, 0.047, 0.081, 0.169) were not statistically significant (all >0.05). BQD chewers showed a decrease dynamic ReHo and/or ALFF in multiple brain regions dominated by prefrontal cortex, and an increase dynamic ReHo in the right precuneus.
探讨槟榔依赖者脑自发活动的动态特征及其与临床指标的关系。本研究于2019年4月至12月在海南总医院进行，收集了53名槟榔依赖者（男37例，女16例，年龄20至58（38±11）岁）和37名健康对照者（男24例，女13例，年龄23 - 57（42±12）岁）的数据。所有受试者均接受静息态功能磁共振成像（rs - fMRI）扫描。采用滑动时间窗方法计算这些受试者静息fMRI指标的动态特征，包括低频波动动态幅度（ALFF）、局部一致性（ReHo）和中心度（DC），分析并比较两组之间的年龄和动态局部一致性等参数。采用Pearson相关性分析槟榔依赖组动态指标、槟榔依赖评分（BQDS）与病程之间的关系。槟榔依赖者左侧眶额前皮质的动态ALFF低于健康对照者（0.138±0.041 vs 0.171±0.070），右侧颞极上颞回（0.277±0.070 vs 0.319±0.086）和右侧顶下小叶（0.223±0.052 vs 0.259±0.088）（均P<0.05）。对于局部一致性，槟榔依赖者右侧颞下回（0.055±0.008 vs 0.061±0.009）、眶额前皮质（0.058±0.005 vs 0.063±0.008）、右侧额下回（0.081±0.006 vs 0.087±0.011）、右侧枕上回（0.056±0.007 vs 0.062±0.008）、左侧中央前回（0.068±0.008 vs 0.074±0.008）和左侧额上回（0.058±0.008 vs 0.064±0.009）的动态ReHo低于健康对照者（均P<0.05）。槟榔依赖者右侧楔前叶的动态ReHo高于健康对照者（0.095±0.009 vs 0.089±0.008）（P<0.05）。两组之间的DC无显著差异（均P>0.05）。三个动态ALFF与BQDS（r = -0.104，-0.015，-0.119）、七个动态ReHo与BQDS（r = -0.099，-0.141，-0.055，-0.078，-0.027，-0.111，-0.
