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与晚期癌症患者善终相关的因素:日本的一项前瞻性研究。

Factors associated with good death of patients with advanced cancer: a prospective study in Japan.

机构信息

Department of Respiratory Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Department of Palliative Medicine, Tohoku University School of Medicine, Sendai, Japan.

出版信息

Support Care Cancer. 2022 Nov;30(11):9577-9586. doi: 10.1007/s00520-022-07363-1. Epub 2022 Sep 20.

Abstract

PURPOSE

It is important for palliative care providers to identify what factors are associated with a "good death" for patients with advanced cancer. We aimed to identify factors associated with a "good death" evaluated by the Good Death Scale (GDS) score among inpatients with advanced cancer in palliative care units (PCUs) in Japan.

METHODS

The study is a sub-analysis of a multicenter prospective cohort study conducted in Japan. All variables were recorded on a structured data collecting sheet designed for the study. We classified each patient into better GDS group or worse GDS group, and examined factors associated with better GDS using multivariate analysis.

RESULTS

Between January and December 2017, 1896 patients were enrolled across 22 PCUs in Japan. Among them, a total of 1157 patients were evaluated. Five variables were significantly associated with a better GDS score in multivariate analysis: preferred place of death at PCU (odds ratio [OR] 2.85; 95% confidence interval [CI] 1.72-4.71; p < 0.01), longer survival time (OR 1.02; 95% CI 1.00-1.03; p < 0.01), not sudden death (OR 1.96; 95% CI 1.27-3.04; p < 0.01), better spiritual well-being in the last 3 days in life (OR 0.53; 95% CI 0.42-0.68; p < 0.01), and better communication between patient and family (OR 0.81; 95% CI 0.66-0.98; p = 0.03).

CONCLUSIONS

We identified factors associated with a "good death" using GDS among advanced cancer patients in Japanese PCUs. Recognition of factors associated with GDS could help to improve the quality of end-of-life care.

摘要

目的

识别与晚期癌症患者“善终”相关的因素对于姑息治疗提供者来说非常重要。我们旨在确定与日本姑息治疗病房(PCU)中晚期癌症患者的善终量表(GDS)评分相关的因素。

方法

该研究是在日本进行的多中心前瞻性队列研究的子分析。所有变量均记录在为研究设计的结构化数据采集表上。我们将每个患者分为 GDS 评分更好的组或更差的组,并使用多变量分析检查与 GDS 评分更好相关的因素。

结果

2017 年 1 月至 12 月期间,在日本的 22 个 PCU 共纳入了 1896 名患者。其中,共有 1157 名患者接受了评估。在多变量分析中,有五个变量与 GDS 评分更好显著相关:在 PCU 中选择的死亡地点(优势比 [OR] 2.85;95%置信区间 [CI] 1.72-4.71;p<0.01)、较长的生存时间(OR 1.02;95% CI 1.00-1.03;p<0.01)、非突然死亡(OR 1.96;95% CI 1.27-3.04;p<0.01)、生命最后 3 天的精神幸福感更好(OR 0.53;95% CI 0.42-0.68;p<0.01)和患者与家属之间的沟通更好(OR 0.81;95% CI 0.66-0.98;p=0.03)。

结论

我们使用 GDS 确定了与日本 PCU 中晚期癌症患者“善终”相关的因素。认识与 GDS 相关的因素可以帮助提高临终关怀的质量。

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