Gladman D D, Urowitz M B
J Rheumatol Suppl. 1987 Jun;14 Suppl 13:223-6.
Over the past 30 years there has been an increase in the survival rate in systemic lupus erythematosus (SLE). As patients with SLE live longer, clinicians involved in their care are confronted with the longterm morbid complications that result either from previous SLE disease itself or as a complication of therapy. Our paper deals with the changing pattern of morbidity in SLE and specifically highlights 3 aspects: atherosclerosis, avascular necrosis and neuropsychological dysfunction. These must be considered as added features in the disease spectrum of SLE.
在过去30年里，系统性红斑狼疮（SLE）的生存率有所提高。随着SLE患者寿命延长，参与其治疗的临床医生面临着由既往SLE疾病本身或治疗并发症导致的长期病态并发症。我们的论文探讨了SLE发病率的变化模式，并特别强调了三个方面：动脉粥样硬化、无血管性坏死和神经心理功能障碍。这些必须被视为SLE疾病谱中的附加特征。
