Sorger P K, Pelham H R
J Mol Biol. 1987 Mar 20;194(2):341-4. doi: 10.1016/0022-2836(87)90380-9.
We report the sequence of a cDNA clone that encodes the C-terminal half of the hamster 94 X 10(3) Mr glucose-regulated protein, grp94. The amino acid sequence of this protein is about 50% homologous to Drosophila hsp83 and yeast hsp90, suggesting that grp94 and hsp90 have similar functional properties. Unlike hsp90, grp94 is associated with the endoplasmic reticulum. It has the same C-terminal tetrapeptide as two other luminal endoplasmic reticulum proteins, grp78 and protein disulphide isomerase. We suggest that this sequence forms part of a signal for retention of proteins in the lumen of the endoplasmic reticulum.
我们报道了一个cDNA克隆的序列，该克隆编码仓鼠94×10³Mr葡萄糖调节蛋白（grp94）的C端一半。该蛋白的氨基酸序列与果蝇hsp83和酵母hsp90约50%同源，表明grp94和hsp90具有相似的功能特性。与hsp90不同，grp94与内质网相关。它与另外两种内质网腔蛋白grp78和蛋白二硫键异构酶具有相同的C端四肽。我们认为该序列构成了内质网腔中蛋白质滞留信号的一部分。
