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第一届蛋白稳态秋令营:从分子机制到机体后果。

The first Autumn School on Proteostasis: from molecular mechanisms to organismal consequences.

机构信息

Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.

Brigham Women's Hospital, Harvard Medical School, Boston, MA, USA.

出版信息

Cell Stress Chaperones. 2019 May;24(3):481-492. doi: 10.1007/s12192-019-00998-w. Epub 2019 May 9.

Abstract

The first Autumn School on Proteostasis was held at the Mediterranean Institute for Life Sciences (MedILS) in Split, Croatia, from November 12th-16th, 2018, bringing together 44 graduate students and postdoctoral fellows and 22 principal investigators from around the world. This meeting was geared towards providing students with an in-depth understanding of the field of proteostasis, with the aim of broadening their perspectives of the field. Session topics covered multiple aspects of cellular and organismal proteostasis, including fundamental principles, responses to heat shock, aging and disease, and protein folding, misfolding, and degradation. The structure of the meeting and the restricted number of participants afforded the students and postdocs the opportunity to interact with principal investigators to discuss not only their latest research, but also their career prospects and progression in a close, supportive environment.

摘要

第一届蛋白稳态秋令营于 2018 年 11 月 12 日至 16 日在克罗地亚斯普利特的地中海生命科学研究所(MedILS)举行,来自世界各地的 44 名研究生和博士后研究员以及 22 名首席研究员参加了此次会议。本次会议旨在为学生提供对蛋白稳态领域的深入了解,以期拓宽他们对该领域的视野。会议的议题涵盖了细胞和生物整体蛋白稳态的多个方面,包括基本原理、对热休克、衰老和疾病的响应以及蛋白质折叠、错误折叠和降解。会议的结构和有限的参与人数使学生和博士后有机会与首席研究员互动,不仅讨论他们的最新研究,还在一个密切、支持性的环境中讨论他们的职业前景和进展。

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本文引用的文献

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Mechanisms of Cotranslational Maturation of Newly Synthesized Proteins.新生蛋白质共翻译成熟的机制。
Annu Rev Biochem. 2019 Jun 20;88:337-364. doi: 10.1146/annurev-biochem-013118-111717. Epub 2018 Dec 3.
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Small heat shock proteins: Simplicity meets complexity.小分子热休克蛋白:简约与复杂的完美结合。
J Biol Chem. 2019 Feb 8;294(6):2121-2132. doi: 10.1074/jbc.REV118.002809. Epub 2018 Oct 31.

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