Mullins J, Seaton A
Clin Allergy. 1978 Sep;8(5):525-33. doi: 10.1111/j.1365-2222.1978.tb01506.x.
A survey of fungal aerospora over a 2-year period was combined with an investigation of the fungi cultured from 295 samples of peripheral human lung and 2466 samples of sputum over the same period. 83% of lung and 88% of sputum samples contained culturable fungi, although in 16% of lung and 31% of sputum samples Candida albicans was the only one. Those fungi of small spore size tended to be found in lung tissue while those with larger spores were more likely to be found in the sputum. While their presence in the respiratory tract was related to their occurrence in the air, differences in their frequencies in the air and lung suggested that the lung had a selective inhibitory effect on the development of different spores. In particular, Aspergillus fumigatus was cultured more frequently than would have been anticipated from its profusion in the air.
对两年期间真菌气传孢子的调查与同期对295份人外周肺样本和2466份痰样本培养的真菌的调查相结合。83%的肺样本和88%的痰样本含有可培养真菌，尽管在16%的肺样本和31%的痰样本中白色念珠菌是唯一的真菌。小孢子大小的真菌倾向于在肺组织中发现，而大孢子真菌更可能在痰中发现。虽然它们在呼吸道中的存在与它们在空气中的出现有关，但它们在空气和肺中的频率差异表明，肺对不同孢子的发育有选择性抑制作用。特别是，烟曲霉在培养中的出现频率高于根据其在空气中的大量存在所预期的频率。
