Department of Cardiology, 117914Chengde Medical University Affiliated Hospital, Chengde, Hebei, China.
Central Laboratory of Chengde Medical University Affiliated Hospital, Chengde, Hebei, China.
Clin Appl Thromb Hemost. 2022 Jan-Dec;28:10760296221128021. doi: 10.1177/10760296221128021.
Novel pro- and anti-inflammatory adipocytokines affect inflammation, energy metabolism, and insulin signaling. However, their role in acute coronary syndrome (ACS) development is unclear. We evaluated the diagnostic and risk predictive value of such adipocytokines for ACS.
We enrolled 168 consecutive inpatients with suspected ACS and detected serum PLIN1, PLIN2, PLIN5, CTRP6, CTRP7, CTRP11, WISP1, FAM19A5, TNF-α, and adiponectin levels. Multivariate logistic regression analysis and Spearman's test were used to assess risk factors for ACS and correlations between serum adipocytokines and continuous variables, respectively.
Serum levels of the adipocytokines differed between ACS and Non-ACS groups ( < 0.05). After adjusting for confounding factors, serum PLIN1, PLIN2, PLIN5, CTRP6, CTRP7, CTRP11, WISP1, and FAM19A5 levels were independently associated with ACS ( < 0.05). Increasing tertiles of serum PLIN1, PLIN2, CTRP7, CTRP11, and WISP1 levels increased the ACS risk, which decreased gradually with increasing PLIN5 and CTRP6 tertiles ( for trend <0.05). Serum PLIN1, PLIN5, CTRP6, CTRP7, CTRP11, WISP1, and FAM19A5 levels correlated with ACS severity.
PLIN1, PLIN2, CTRP7, CTRP11, and WISP1 were identified as independent ACS risk factors, whereas PLIN5, CTRP6, and FAM19A5 were independent protective factors for ACS. These serum adipocytokines are novel potential clinical biomarkers of ACS.
新型促炎和抗炎脂肪细胞因子影响炎症、能量代谢和胰岛素信号。然而，它们在急性冠状动脉综合征（ACS）发展中的作用尚不清楚。我们评估了这些脂肪细胞因子对 ACS 的诊断和风险预测价值。
我们连续纳入 168 例疑似 ACS 的住院患者，检测血清 PLIN1、PLIN2、PLIN5、CTRP6、CTRP7、CTRP11、WISP1、FAM19A5、TNF-α 和脂联素水平。采用多变量逻辑回归分析和 Spearman 检验分别评估 ACS 的危险因素和血清脂肪细胞因子与连续变量之间的相关性。
ACS 组和非 ACS 组的血清脂肪细胞因子水平不同（ < 0.05）。在校正混杂因素后，血清 PLIN1、PLIN2、PLIN5、CTRP6、CTRP7、CTRP11、WISP1 和 FAM19A5 水平与 ACS 独立相关（ < 0.05）。血清 PLIN1、PLIN2、CTRP7、CTRP11 和 WISP1 水平递增 tertile 增加 ACS 风险，而 PLIN5 和 CTRP6 水平递增 tertile 则逐渐降低 ACS 风险（趋势检验 < 0.05）。血清 PLIN1、PLIN5、CTRP6、CTRP7、CTRP11、WISP1 和 FAM19A5 水平与 ACS 严重程度相关。
PLIN1、PLIN2、CTRP7、CTRP11 和 WISP1 被确定为 ACS 的独立危险因素，而 PLIN5、CTRP6 和 FAM19A5 是 ACS 的独立保护因素。这些血清脂肪细胞因子是 ACS 的潜在新型临床生物标志物。
