Centro de Investigación Aplicada en Ambiente Y Salud (CIAAS), Colonia Lomas Segunda Sección, Avenida Sierra Leona No. 550, CP, 78210, San Luis Potosí, SLP, México.
Unidad de Innovación en Diagnóstico Celular Y Molecular. Coordinación Para La Innovación Y La Aplicación de La Ciencia Y Tecnología, Universidad Autónoma de San Luis Potosí Av, Sierra Leona 550, Lomas 2a sección, 78120, San Luis Potosí, SLP, México.
Environ Sci Pollut Res Int. 2023 Jan;30(5):13270-13282. doi: 10.1007/s11356-022-23071-z. Epub 2022 Sep 21.
Brick production causes a lot of pollution in the form of dust, fumes, and toxic substances. Therefore, brick workers are highly exposed to pollutants and present a high risk of developing respiratory diseases. The objective of this research was to determine the exposure to polycyclic aromatic hydrocarbons (PAHs) and toluene in urine and evaluate the effects on health using markers of oxidative stress in exhaled breath condensate (EBC) as well as the exposure to pollutants in suspended particles of the studied area. Exposure to PAHs and toluene was evaluated using hydroxylated markers (OH) of PAHs and hippuric acid in urine, respectively. Cytokines like TNF-α, INF-y, IL-2, IL-4, IL-6, IL-8, IL-10 y GMCSF in EBC were also evaluated. PM particles were measured during an 8-h work shift. The results in brick workers presented a total OH-PAHs concentration of 97.3 µg/L and hippuric acid concentration of 0.2 g/L. The environmental concentrations of suspended particles were found within a range of 41.67-3541.6 μg/m. The median of cytokines oscillated between 11.8 pg/mL to 1041 pg/mL. In conclusion, these results are similar to those of occupations in which there is high exposure to pollutants and populations with lung diseases. For that reason, the brick production sector requires prevention and control strategies against the pollutants emitted.
制砖过程会产生大量的粉尘、烟雾和有毒物质，造成严重的污染。因此，砖厂工人会接触到大量污染物，面临更高的罹患呼吸疾病的风险。本研究的目的是确定工人尿液中多环芳烃（PAHs）和甲苯的暴露水平，并通过呼出气冷凝物（EBC）中的氧化应激标志物以及研究区域悬浮颗粒物中污染物的暴露情况来评估其对健康的影响。分别用尿液中 PAHs 的羟基化标志物（OH）和马尿酸来评估 PAHs 和甲苯的暴露情况。还评估了 EBC 中的细胞因子，如 TNF-α、INF-y、IL-2、IL-4、IL-6、IL-8、IL-10 和 GMCSF。在 8 小时的工作班次中测量了 PM 颗粒。结果显示，砖厂工人尿液中的总 OH-PAHs 浓度为 97.3µg/L，马尿酸浓度为 0.2g/L。悬浮颗粒物的环境浓度在 41.67-3541.6µg/m 之间。细胞因子的中位数在 11.8pg/mL 到 1041pg/mL 之间波动。总之，这些结果与那些高污染暴露的职业和患有肺部疾病的人群相似。因此，制砖行业需要采取针对污染物排放的预防和控制策略。
