Comeche B, Pérez-Butragueño M, Cuadros J, Tiziano G, Górgolas M, Ramos-Rincón J M
Belén Comeche, Servicio de Medicina Interna, Hospital Universitario Infanta Leonor, Madrid, Spain.
Rev Esp Quimioter. 2022 Dec;35(6):559-562. doi: 10.37201/req/052.2022. Epub 2022 Sep 22.
To evaluate the implementation of Xpert-MTB/RIF®, as an early diagnosis technique, in a rural area of Ethiopia.
Data were retrospectively collected from those patients over 13 years of age who were requested to take the Xpert MTB/RIF® test in a rural hospital located 45 km from the reference laboratory, during the first 3 years of its implementation (2015, April -2018, April).
A total of 306 patients older than 13 years were evaluated, in 85 (27.8%) there was an error in the processing of the test and the result was not obtained. Of the 221 samples with results, the median time between obtaining the sample and receiving the result was 21 days and 42 of them were positive (19%, 95% CI: 14.2-24.9%). The sample with the highest diagnostic yield was adenopathy (88.8%; [8/9]; p<0.001).
There are more bacteriological diagnoses with Xpert-MTB/RIF®, but with a delay in obtaining the result and its main objective, which is early diagnosis, is not achieved.
评估在埃塞俄比亚农村地区将Xpert-MTB/RIF®作为一种早期诊断技术的实施情况。
回顾性收集了在距离参考实验室45公里的一家农村医院实施该技术的前3年（2015年4月至2018年4月）期间，13岁以上被要求进行Xpert MTB/RIF®检测的患者的数据。
共评估了306名13岁以上的患者，其中85名（27.8%）检测过程出现错误，未获得检测结果。在获得结果的221份样本中，从获取样本到收到结果的中位时间为21天，其中42份呈阳性（19%，95%可信区间：14.2-24.9%）。诊断阳性率最高的样本是腺病（88.8%；[8/9]；p<0.001）。
使用Xpert-MTB/RIF®进行的细菌学诊断更多，但在获取结果方面存在延迟，且未实现其早期诊断的主要目标。
