从 的根部分离得到两个新的二甲基色酮基二氢黄酮。
Two new dimethylpyranoflavanones from the roots of .
机构信息
Department of Chemistry, University of Science, HCM National University, Ho Chi Minh City, Vietnam.
Institute of Environment-Energy Technology, Sai Gon University, Ho Chi Minh City, Vietnam.
出版信息
Nat Prod Res. 2024 Jan-Feb;38(3):433-439. doi: 10.1080/14786419.2022.2126467. Epub 2022 Sep 21.
Two previously unreported dimethylpyranoflavanones, pyronomelodorones A and B ( and ), along with five known compounds, 7--methyldihydrowogonin (), 5,6,7-trimethoxyflavanone (), 5,6-dihydroxy-7-methoxy-dihydroflavone (), 5,7,8-trimethoxydihydroflavone (), and pinostrobin (), were isolated from the roots of The structures of all isolates were fully characterized using spectroscopic data and comparison with the previous literature. All isolates were evaluated for their -glucosidase inhibition and their cytotoxicity against KB, HepG2, and MCF7 cell lines. Among the isolates, compound exhibited the most inhibitory activity against -glucosidase and was superior to the positive control with an IC value of 1.32 M. Compounds and showed weak cytotoxicity against the three human cancer cell lines, with IC values in the range of 53.3-79.0 M.
从 的根部分离得到两种以前未报道的二甲氧基紫檀烷酮，即 pyronomelodorone A 和 B（和），以及五种已知化合物，7--甲基二氢沃格尔宁（）、5,6,7-三甲氧基黄烷酮（）、5,6-二羟基-7-甲氧基二氢黄酮（）、5,7,8-三甲氧基二氢黄酮（）和 pinostrobin（）。所有分离物的结构均通过光谱数据和与先前文献的比较进行了充分表征。所有分离物均评估了其对 -葡萄糖苷酶的抑制作用及其对 KB、HepG2 和 MCF7 细胞系的细胞毒性。在分离物中，化合物 对 -葡萄糖苷酶的抑制活性最强，IC 值为 1.32 M，优于阳性对照。化合物 和 对三种人癌细胞系表现出较弱的细胞毒性，IC 值范围为 53.3-79.0 M。
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