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锡叶藤叶成分对人中性粒细胞促炎功能的抑制作用

Inhibition of Pro-Inflammatory Functions of Human Neutrophils by Constituents of Melodorum fruticosum Leaves.

作者信息

Engels Nora S, Waltenberger Birgit, Michalak Barbara, Huynh Loi, Tran Hung, Kiss Anna K, Stuppner Hermann

机构信息

Institute of Pharmacy/Pharmacognosy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innrain 80-82, 6020, Innsbruck, Austria.

Department of Pharmacognosy and Molecular Basis of Phytotherapy, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097, Warsaw, Poland.

出版信息

Chem Biodivers. 2018 Nov;15(11):e1800269. doi: 10.1002/cbdv.201800269. Epub 2018 Nov 15.

DOI:10.1002/cbdv.201800269
PMID:30193010
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6468251/
Abstract

In an initial screening, the dichloromethane extract from the leaves of Melodorum fruticosum showed distinct inhibitory effects on the release of interleukin-8 (IL-8) in human neutrophils. Therefore, the aim of the present study was the phytochemical and pharmacological investigation of this extract, to better understand which compounds might be responsible for the anti-inflammatory effect. Phytochemical analysis led to the isolation of 12 known compounds and two new natural products, 5-hydroxy-6-(2-hydroxybenzyl)-4',7-dimethoxyflavanone (13) and 2',4'-dihydroxy-3'-(2-hydroxybenzyl)-4,6'-dimethoxychalcone (14). The influence of the isolated compounds on the production and release of the pro-inflammatory factors IL-8, tumor necrosis factor alpha (TNF-α), reactive oxygen species (ROS), and adhesion molecules (CD62L and CD11b) in human neutrophils was evaluated. Three constituents, melodamide A, 2',4'-dihydroxy-4,6'-dimethoxychalcone, and 2',6'-dihydroxy-4'-methoxychalcone, showed significant inhibition of IL-8 release (IC =6.6, 8.6, and 11.6 μm, respectively) and TNF-α production (IC =4.5, 13.3, and 6.2 μm, respectively).

摘要

在初步筛选中，紫玉盘叶的二氯甲烷提取物对人中性粒细胞中白细胞介素-8（IL-8）的释放显示出明显的抑制作用。因此，本研究的目的是对该提取物进行植物化学和药理学研究，以更好地了解哪些化合物可能是抗炎作用的原因。植物化学分析导致分离出12种已知化合物和两种新的天然产物，5-羟基-6-（2-羟基苄基）-4'，7-二甲氧基黄酮（13）和2'，4'-二羟基-3'-（2-羟基苄基）-4,6'-二甲氧基查耳酮（14）。评估了分离出的化合物对人中性粒细胞中促炎因子IL-8、肿瘤坏死因子α（TNF-α）、活性氧（ROS）和粘附分子（CD62L和CD11b）的产生和释放的影响。三种成分，紫玉盘酰胺A、2'，4'-二羟基-4,6'-二甲氧基查耳酮和2'，6'-二羟基-4'-甲氧基查耳酮，对IL-8释放（IC分别为6.6、8.6和11.6 μ m）和TNF-α产生（IC分别为4.5、13.3和6.2 μ m）显示出显著抑制作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d0c/6468251/f9538cadca15/CBDV-15-na-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d0c/6468251/0dab04901e4f/CBDV-15-na-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d0c/6468251/ec9a20e8e739/CBDV-15-na-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d0c/6468251/bd7e6316fdd4/CBDV-15-na-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d0c/6468251/072cc22ad897/CBDV-15-na-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d0c/6468251/6e036b9acd79/CBDV-15-na-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d0c/6468251/7173f2c45348/CBDV-15-na-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d0c/6468251/f9538cadca15/CBDV-15-na-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d0c/6468251/0dab04901e4f/CBDV-15-na-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d0c/6468251/ec9a20e8e739/CBDV-15-na-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d0c/6468251/bd7e6316fdd4/CBDV-15-na-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d0c/6468251/072cc22ad897/CBDV-15-na-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d0c/6468251/6e036b9acd79/CBDV-15-na-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d0c/6468251/7173f2c45348/CBDV-15-na-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6d0c/6468251/f9538cadca15/CBDV-15-na-g007.jpg

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