从 中得到的新类黄酮衍生物及其α-葡萄糖苷酶抑制和细胞毒性活性。
New Flavonoid Derivatives from and Their α-Glucosidase Inhibitory and Cytotoxic Activities.
机构信息
Sai Gon University, Ho Chi Minh City 748355, Vietnam.
Research Unit in Natural Products Chemistry and Bioactivities, Faculty of Science and Technology, Thammasat University Lampang Campus, Lampang 52190, Thailand.
出版信息
Molecules. 2022 Jun 22;27(13):4023. doi: 10.3390/molecules27134023.
Three new flavonoid derivatives, melodorones A-C (-), together with four known compounds, tectochrysin (), chrysin (), onysilin (), and pinocembrin (), were isolated from the stem bark of Their structures were determined on the basis of extensive spectroscopic methods, including NMR and HRESIMS, and by comparison with the literature. Compounds - were evaluated for their in vitro α-glucosidase inhibition and cytotoxicity against KB, Hep G2, and MCF7 cell lines. Among them, compound exhibited the best activity against -glucosidase and was superior to the positive control with an IC value of 2.59 μM. On the other hand, compound showed moderate cytotoxicity toward KB, Hep G2, and MCF7 cell lines with the IC values of 23.5, 19.8, and 23.7 μM, respectively. These findings provided new evidence that the stem bark of is a source of bioactive flavonoid derivatives that are highly valuable for medicinal development.
从该植物的茎皮中分离得到了三个新的黄酮类衍生物（melodorones A-C (-)），以及四个已知化合物：tectochrysin (), chrysin (), onysilin (), 和 pinocembrin ()。它们的结构是基于广泛的光谱方法确定的，包括 NMR 和 HRESIMS，并与文献进行了比较。对化合物 - 进行了体外α-葡萄糖苷酶抑制活性和对 KB、Hep G2 和 MCF7 细胞系的细胞毒性评估。其中，化合物 对 -葡萄糖苷酶表现出最好的抑制活性，IC 值为 2.59 μM，优于阳性对照。另一方面，化合物 对 KB、Hep G2 和 MCF7 细胞系表现出中等的细胞毒性，IC 值分别为 23.5、19.8 和 23.7 μM。这些发现为该植物的茎皮是具有重要药用开发价值的生物活性黄酮类衍生物的来源提供了新的证据。
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